Epigenomics as a paradigm to understand the nuances of phenotypes
C Fanter, C Madelaire, DP Genereux… - Journal of …, 2022 - journals.biologists.com
Quantifying the relative importance of genomic and epigenomic modulators of phenotype is
a focal challenge in comparative physiology, but progress is constrained by availability of …
a focal challenge in comparative physiology, but progress is constrained by availability of …
The three-dimensional landscape of cortical chromatin accessibility in Alzheimer's disease
To characterize the dysregulation of chromatin accessibility in Alzheimer's disease (AD), we
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …
Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains
Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-
ranging domains encompassing multiple transcriptional units, including heritability loci for …
ranging domains encompassing multiple transcriptional units, including heritability loci for …
Multi-view clustering for integration of gene expression and methylation data with tensor decomposition and self-representation learning
X Gao, Y Wang, W Hou, Z Liu… - IEEE/ACM Transactions on …, 2022 - ieeexplore.ieee.org
The accumulated DNA methylation and gene expression provide a great opportunity to
exploit the epigenetic patterns of genes, which is the foundation for revealing the underlying …
exploit the epigenetic patterns of genes, which is the foundation for revealing the underlying …
An effective approach for CT lung segmentation using region growing
X Yang, G Xu, T Zhou - Journal of Physics: Conference Series, 2021 - iopscience.iop.org
X-ray is an important means of detecting lung diseases. With the increasing incidence of
lung diseases, computer-aided diagnosis technology is of great significance in clinical …
lung diseases, computer-aided diagnosis technology is of great significance in clinical …
[HTML][HTML] Sex differences in brain cell-type specific chromatin accessibility in schizophrenia
Our understanding of the sex-specific role of the non-coding genome in serious mental
illness remains largely incomplete. To address this gap, we explored sex differences in …
illness remains largely incomplete. To address this gap, we explored sex differences in …
Acetylated chromatin domains link chromosomal organization to cell-and circuit-level dysfunction in schizophrenia and bipolar disorder
To explore modular organization of chromosomes in schizophrenia (SCZ) and bipolar
disorder (BD), we applied 'population-scale'correlational structuring of 739 histone H3-lysine …
disorder (BD), we applied 'population-scale'correlational structuring of 739 histone H3-lysine …
ATAC-seq and psychiatric disorders
A growing number of genetic loci are associated with increased risk for psychiatric disease.
Most reside within non-coding regions of the genome and are thought to contribute to …
Most reside within non-coding regions of the genome and are thought to contribute to …