In 1963, Prelog and co-workers determined the chemical structure of various rifamycins
(122) and opened up the way for the synthesis of a vast number of semisynthetic derivatives …

Publisher Summary The discovery of RNA-directed DNA synthesis in disrupted virions of
RNA tumor viruses added strong support to the hypothesis that information transfer from …

Duck hepatitis B virus, a DNA virus closely related to human hepatitis B virus, was studied in
infected duck liver. Subviral particles resembling the viral nucleocapsid cores were isolated …

DURING replication of RNA tumour viruses, the genetic information contained in the viral
RNA seems to be transferred to DNA1, 2. Studies on the enzymatic activities present in the …

A model is presented according to which cauliflower mosaic virus (CaMV) DNA is replicated
via an RNA intermediate. The model explains the typical Sl nuclease-sensitive sites in …

Publisher Summary This chapter discusses polyenes in clinical use and those polyenes with
properties that contribute to the understanding of the mechanism of action of the group as a …

In the summer of 1970, Baltimore [1] and Temin and Mizutani [2] reported the presence of a
DNA polymerase in the virions of RNA tumor viruses. The viral RNA acted as the template to …

Often when an antibiotic of a new structural type appears on the chemotherapeutic scene it
is soon joined by additional representatives of the same type, so that one can begin to speak …

It is probably too early for a conclusive review on the rifamycins. In fact, while the various
asp cts of their antibacterial activity are adequately under stood, the same is not true for …

The ansamycin antibiotics derive their name from the characteristic configuration of their
molecule, which consists of a fiat aromatic nucleus and a long aliphatic bridge, shaped like a …