The relative contributions of insulin resistance and beta-cell dysfunction to the
pathophysiology of Type 2 diabetes have been debated extensively. The concept that a …

The pathogenesis of type 2 diabetes is complex and in most instances clearly requires
defects in both ß-cell function and insulin sensitivity (1). Together, these abnormalities result …

The intestinally derived hormone glucagon-like peptide 1 (GLP-1)(7-36 amide) has potent
effects on glucose-mediated insulin secretion, insulin gene expression, and β-cell growth …

The increased prevalence of non-insulin-dependent diabetes mellitus (NIDDM) among
women with polycystic ovary syndrome (PCOS) has been ascribed to the insulin resistance …

Background: β-Cell dysfunction is a core defect in T2DM, and chronic, sustained
hyperglycemia has been implicated in progressive β-cell failure, ie, glucotoxicity. The aim of …

Assessment of insulin secretion in humans under physiological conditions has been a
challenge because of its complex interplay with insulin action and hepatic insulin extraction …

The quantitative assessment of insulin sensitivity (IS) and β-cell function (BCF) is
fundamental in the study of metabolic disorders. The most relevant experimental tests and …

We investigated β-cell function and its relationship to insulin sensitivity in 17 normal
volunteers. For insulin secretion (derived by C-peptide deconvolution), a mathematical …

Hyperinsulinemia contributes to the ovarian androgen overproduction and glucose
intolerance of polycystic ovary syndrome (PCOS). We sought to determine whether …

The in vivo effect of elevated free fatty acids (FFA) on β-cell function in humans remains
extremely controversial. We examined, in healthy young men, the acute (90 min) and …