During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …

Perfluorinated and polyfluorinated alkyl substances (PFAS), more than 4700 in number, are
a group of widely used man-made chemicals that accumulate in living things and the …

Environmental chemicals comprise a major portion of the human exposome, with some
shown to impact the health of susceptible populations, including pregnant women and …

In vivo, the interior and exterior of cells is populated by various macromolecules that create
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …

The safety assessments for chemicals targeted for use or expected to be exposed to specific
life stages, including infancy, childhood, pregnancy and lactation, and geriatrics, need to …

Chemical risk assessment relies on knowledge of hazard, the dose–response relationship,
and exposure to characterize potential risks to public health and the environment. A …

An understanding of the postnatal development of hepatic UDP‐glucuronosyltransferase
(UGT) enzymes is required for accurate prediction of the age‐dependent changes in …

Physiologically based pharmacokinetic (PBPK) modeling is used to predict the
pharmacokinetic behavior of xenobiotics in humans. During pregnancy, anatomical and …

Background: There is a great concern on potential adverse effects of exposure to
perfluorooctane sulfonate (PFOS) in sensitive subpopulations, such as pregnant women …

Background The developmental toxicity potential (dTP) concentration from the devTOX quick
Predict (devTOX qP) assay, a metabolomics‐based human induced pluripotent stem cell …