Transcription factors as key molecular target to strengthen the drought stress tolerance in plants
Amid apprehension of global climate change, crop plants are inevitably confronted with a
myriad of abiotic stress factors during their growth that inflicts a serious threat to their …
myriad of abiotic stress factors during their growth that inflicts a serious threat to their …
Protein assembly: versatile approaches to construct highly ordered nanostructures
Nature endows life with a wide variety of sophisticated, synergistic, and highly functional
protein assemblies. Following Nature's inspiration to assemble protein building blocks into …
protein assemblies. Following Nature's inspiration to assemble protein building blocks into …
The AP-1 transcriptional complex: Local switch or remote command?
F Bejjani, E Evanno, K Zibara, M Piechaczyk… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all
cellular and physiological functions. It is paramount for cells to reprogram gene expression …
cellular and physiological functions. It is paramount for cells to reprogram gene expression …
Accurate prediction of protein function using statistics-informed graph networks
Understanding protein function is pivotal in comprehending the intricate mechanisms that
underlie many crucial biological activities, with far-reaching implications in the fields of …
underlie many crucial biological activities, with far-reaching implications in the fields of …
ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression
Skeletal muscle stem cells (also called satellite cells, SCs) are important for maintaining
muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly …
muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly …
Transcription factor binding site orientation and order are major drivers of gene regulatory activity
The gene regulatory code and grammar remain largely unknown, precluding our ability to
link phenotype to genotype in regulatory sequences. Here, using a massively parallel …
link phenotype to genotype in regulatory sequences. Here, using a massively parallel …
AP-1: a double-edged sword in tumorigenesis
R Eferl, EF Wagner - Nature Reviews Cancer, 2003 - nature.com
The AP-1 transcription factor is a dimeric complex that contains members of the JUN, FOS,
ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but …
ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but …
BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers
R Roychoudhuri, D Clever, P Li, Y Wakabayashi… - Nature …, 2016 - nature.com
T cell antigen receptor (TCR) signaling drives distinct responses depending on the
differentiation state and context of CD8+ T cells. We hypothesized that access of signal …
differentiation state and context of CD8+ T cells. We hypothesized that access of signal …
Intrinsic disorder and protein function
The dominant view of protein structure-function is that an amino acid sequence specifies a
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation
Networks of protein interactions coordinate cellular functions. We describe a bimolecular
fluorescence complementation (BiFC) assay for determination of the locations of protein …
fluorescence complementation (BiFC) assay for determination of the locations of protein …