Genetic variations resulting in a change of amino acid sequence can have a dramatic effect
on stability, hydrogen bond network, conformational dynamics, activity and many other …

Highlights•Missense mutations frequently alter protein biophysical characteristics such as
stability, dynamics and interactions.•Protein biophysical properties are interrelated and …

Background Accurate modeling of electrostatic potential and corresponding energies
becomes increasingly important for understanding properties of biological macromolecules …

Non-synonymous single nucleotide polymorphisms (nsSNPs) are single base changes
leading to a change to the amino acid sequence of the encoded protein. Many of these …

Abstract 'Salt & Pepper'syndrome is an autosomal recessive condition characterized by
severe intellectual disability, epilepsy, scoliosis, choreoathetosis, dysmorphic facial features …

Large scale genome sequencing allowed the identification of a massive number of genetic
variations, whose impact on human health is still unknown. In this review we analyze, by an …

Single‐point mutation in genome, for example, single‐nucleotide polymorphism (SNP) or
rare genetic mutation, is the change of a single nucleotide for another in the genome …

Many nonsynonymous single nucleotide polymorphisms (nsSNPs) are disease causing due
to effects at protein‐protein interfaces. We have integrated a database of the three …

Statistical analysis was carried out on large set of naturally occurring human amino acid
variations, and it was demonstrated that there is a preference for some amino acid …

The role of electrostatics in protein–protein interactions and binding is reviewed in this
paper. A brief outline of the computational modeling, in the framework of continuum …