The nematode Caenorhabditis elegans has shed light on many aspects of eukaryotic
biology, including genetics, development, cell biology, and genomics. A major factor in the …

DNA must be accurately copied and propagated from one cell division to the next, and from
one generation to the next. To ensure the faithful transmission of the genome, a plethora of …

Failure to preserve the integrity of the genome is a hallmark of cancer. Recent studies have
revealed that loss of the capacity to repair DNA breaks via homologous recombination (HR) …

DNA double-strand breaks are a major threat to cellular survival and genetic integrity. In
addition to high fidelity repair, three intrinsically mutagenic DNA break repair routes have …

In sexually reproducing organisms, germ cells faithfully transmit the genome to the next
generation by forming haploid gametes, such as eggs and sperm. Although most meiotic …

Meiosis is a specialized cell cycle that results in the production of haploid gametes for
sexual reproduction. During meiosis, homologous chromosomes are connected by …

Sexual reproduction shuffles the parental genomes to generate new genetic combinations.
To achieve that, the genome is subjected to numerous double-strand breaks, the repair of …

DNA double-strand breaks (DSBs) are deleterious lesions, which must be repaired precisely
to maintain genomic stability. During meiosis, programmed DSBs are repaired via …

Successful human reproduction relies on the well-orchestrated development of competent
gametes through the process of meiosis. The loading of cohesin, a multi-protein complex, is …

Protecting chromosome ends from misrecognition as double-stranded (ds) DNA breaks is
fundamental to eukaryotic viability. The protein complex shelterin prevents a DNA damage …