Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer's Disease: Preclinical to Clinical Trial Insights

K Nagori, KT Nakhate, K Yadav, Ajazuddin… - Future …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative
disease characterized by memory loss, personality changes, and cognitive impairment. It …

Alzheimer's disease approaches-Focusing on pathology, biomarkers and clinical trial candidates

J Hroudová, Z Fišar - Progress in Neuro-Psychopharmacology and …, 2024 - Elsevier
The strategy for the development of new drugs for Alzheimer's disease (AD) recognizes that
an effective therapy requires early therapeutic intervention and a multifactorial approach that …

[HTML][HTML] A 4.7-kDa polysaccharide from Panax ginseng suppresses Aβ pathology via mitophagy activation in cross-species Alzheimer's disease models

S Zhang, F Liu, J Li, C Jing, J Lu, X Chen… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurological condition that progresses with age. Amyloid-β
(Aβ) aggregation has been suggested to be a key pathogenic process in Alzheimer's …

Genistein alleviates pulmonary fibrosis by inactivating lung fibroblasts

S Kwon, H Chung, JW Seo, HS Kim - BMB reports, 2023 - pmc.ncbi.nlm.nih.gov
Pulmonary fibrosis is a serious lung disease that occurs predominantly in men. Genistein is
an important natural soybean-derived phytoestrogen that affects various biological functions …

Korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in Alzheimer's disease

S Kim, SJ Shin, Y Nam, YH Park, BH Kim… - International Journal of …, 2024 - Elsevier
Tau is a microtubule-associated protein that plays a critical role in the stabilization and
modulation of neuronal axons. Tau pathology is stronger associated with cognitive decline …

[HTML][HTML] Non-saponin from Panax ginseng maintains blood-brain barrier integrity by inhibiting NF-κB and p38 MAP kinase signaling pathways to prevent the …

J Oh, Y Ha, TW Kwon, HS Jo, SK Moon, Y Lee… - Journal of Ginseng …, 2024 - Elsevier
Background The non-saponin (NS) fraction is an important active component of Panax
ginseng, with multifunctional pharmacological activities including neuroprotective, immune …

High-dose ascorbic acid synergizes with anti-PD1 therapy in non-small cell lung cancer in vitro and in vivo models

HS Kim, S Kwon, OK Choi, T Lim - Frontiers in Immunology, 2025 - frontiersin.org
Introduction Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1
(PD1) confer significant survival benefits to patients with non-small cell lung cancer …

The Carnitine Palmitoyl-Transferase 2 Cascade Hypothesis for Alzheimer's Disease

HG Keizer, R Brands, RS Oosting… - Journal of Alzheimer's …, 2024 - content.iospress.com
Despite decades of intense research, the precise etiology of Alzheimer's disease (AD)
remains unclear. In this hypothesis, we present a new perspective on this matter by …

Can AD be identified through metabolic models?

G Sandstig - 2024 - odr.chalmers.se
The most common form of dementia is Alzheimer's Disease (AD), a progressive
neurodegenerative disorder, but so far no methods of curing or preventing it are known …