Tailoring photosensitive ROS for advanced photodynamic therapy

DL Sai, J Lee, DL Nguyen, YP Kim - Experimental & molecular …, 2021 - nature.com
Photodynamic therapy (PDT) has been considered a noninvasive and cost-effective
modality for tumor treatment. However, the complexity of tumor microenvironments poses …

The growing and glowing toolbox of fluorescent and photoactive proteins

EA Rodriguez, RE Campbell, JY Lin, MZ Lin… - Trends in biochemical …, 2017 - cell.com
Over the past 20 years, protein engineering has been extensively used to improve and
modify the fundamental properties of fluorescent proteins (FPs) with the goal of adapting …

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

YC Wong, ELF Holzbaur - Proceedings of the National …, 2014 - National Acad Sciences
Mitophagy is a cellular quality control pathway in which the E3 ubiquitin ligase parkin targets
damaged mitochondria for degradation by autophagosomes. We examined the role of …

Fluorescent proteins and their applications in imaging living cells and tissues

DM Chudakov, MV Matz, S Lukyanov… - Physiological …, 2010 - journals.physiology.org
Green fluorescent protein (GFP) from the jellyfish Aequorea victoria and its homologs from
diverse marine animals are widely used as universal genetically encoded fluorescent labels …

Upconversion dual-photosensitizer–expressing bacteria for near-infrared monochromatically excitable synergistic phototherapy

M Chen, Q Han, M Zhang, Y Liu, L Wang, F Yang… - Science …, 2024 - science.org
Synergistic phototherapy stands for superior treatment prospects than a single
phototherapeutic modality. However, the combined photosensitizers often suffer from …

Photoinduced chemistry in fluorescent proteins: curse or blessing?

A Acharya, AM Bogdanov, BL Grigorenko… - Chemical …, 2017 - ACS Publications
Photoinduced reactions play an important role in the photocycle of fluorescent proteins from
the green fluorescent protein (GFP) family. Among such processes are photoisomerization …

Fluorescent proteins for live-cell imaging with super-resolution

K Nienhaus, GU Nienhaus - Chemical Society Reviews, 2014 - pubs.rsc.org
Fluorescent proteins (FPs) from the GFP family have become indispensable as marker tools
for imaging live cells, tissues and entire organisms. A wide variety of these proteins have …

Far-red fluorescence probe for monitoring singlet oxygen during photodynamic therapy

S Kim, T Tachikawa, M Fujitsuka… - Journal of the American …, 2014 - ACS Publications
Singlet oxygen (1O2), molecular oxygen in the lowest excited state, has a critical role in the
cell-killing mechanism of photodynamic therapy (PDT). Although 1O2 phosphorescence …

Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms

N Andenmatten, S Egarter, AJ Jackson, N Jullien… - Nature …, 2013 - nature.com
We established a conditional site-specific recombination system based on dimerizable Cre
recombinase− mediated recombination in the apicomplexan parasite Toxoplasma gondii …

Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms

A Ertürk, Y Wang, M Sheng - Journal of Neuroscience, 2014 - Soc Neuroscience
Synapse loss occurs normally during development and pathologically during
neurodegenerative disease. Long-term depression, a proposed physiological correlate of …