Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Global and regional prevalence and outcomes of COVID-19 in people living with HIV: a systematic review and meta-analysis

T Oyelade, JS Alqahtani, AM Hjazi, A Li… - Tropical medicine and …, 2022 - mdpi.com
Background: The relationship between HIV (human immunodeficiency virus) and COVID-19
clinical outcome is uncertain, with conflicting data and hypotheses. We aimed to assess the …

Evolution and neutralization escape of the SARS-CoV-2 BA. 2.86 subvariant

K Khan, G Lustig, C Römer, K Reedoy, Z Jule… - Nature …, 2023 - nature.com
Abstract Omicron BA. 2.86 subvariant differs from Omicron BA. 2 as well as recently
circulating variants by over 30 mutations in the spike protein alone. Here we report on the …

Omicron BA. 4/BA. 5 escape neutralizing immunity elicited by BA. 1 infection

K Khan, F Karim, Y Ganga, M Bernstein, Z Jule… - Nature …, 2022 - nature.com
Abstract SARS-CoV-2 Omicron (B. 1.1. 529) BA. 4 and BA. 5 sub-lineages, first detected in
South Africa, have changes relative to Omicron BA. 1 including substitutions in the spike …

SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape

S Cele, F Karim, G Lustig, JE San, T Hermanus… - Cell host & …, 2022 - cell.com
Characterizing SARS-CoV-2 evolution in specific geographies may help predict properties
of the variants that come from these regions. We mapped neutralization of a SARS-CoV-2 …

[HTML][HTML] Emergence of new SARS-CoV-2 Variant of Concern Omicron (B. 1.1. 529)-highlights Africa's research capabilities, but exposes major knowledge gaps …

E Petersen, F Ntoumi, DS Hui, A Abubakar… - International Journal of …, 2022 - Elsevier
Nearly two years since the start of the SARS-CoV-2 pandemic, which has caused over 5
million deaths, the world continues to be on high COVID-19 alert. The World Health …

新型冠状病毒Omicron 变异株的流行病学特征及防控研究

吴俣, 刘珏, 刘民, 梁万年 - 中国全科医学, 2022 - chinagp.net
Omicron (B. 1.1. 529) 变异株于2021 年11 月24 日首次从南非报告给世界卫生组织, 截至2021
年12 月8 日全球共有57 个国家和地区报告了Omicron 感染病例. 目前Omicron …

Systematic review and meta-analyses of the interaction between HIV infection and COVID-19: two years' evidence summary

Y Wang, Y Xie, S Hu, W Ai, Y Tao, H Tang… - Frontiers in …, 2022 - frontiersin.org
Introduction During the COVID-19 pandemic, people living with HIV (PLWH) were
considered to be at risk of worse COVID-19 outcomes once infected. However, the existing …

Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition

T Nkosi, C Chasara, AO Papadopoulos, TL Nguni… - Elife, 2022 - elifesciences.org
In some instances, unsuppressed HIV has been associated with severe COVID-19 disease,
but the mechanisms underpinning this susceptibility are still unclear. Here, we assessed the …

SARS-CoV-2 infection in immunosuppression evolves sub-lineages which independently accumulate neutralization escape mutations

G Lustig, Y Ganga, HE Rodel, H Tegally… - Virus …, 2024 - academic.oup.com
One mechanism of variant formation may be evolution during long-term infection in
immunosuppressed people. To understand the viral phenotypes evolved during such …