The ERCC1–XPF complex is a structure-specific endonuclease essential for the repair of
DNA damage by the nucleotide excision repair pathway. It is also involved in other key …

Ageing of the immune system, or immunosenescence, contributes to the morbidity and
mortality of the elderly,. To define the contribution of immune system ageing to organism …

The ERCC1 and ERCC4 genes encode the two subunits of the ERCC1–XPF nuclease. This
enzyme plays an important role in repair of DNA damage and in maintaining genomic …

SLX4 binds to three nucleases (XPF-ERCC1, MUS81-EME1, and SLX1), and its deficiency
leads to genomic instability, sensitivity to DNA crosslinking agents, and Fanconi anemia …

Nucleotide excision repair (NER) is one of the main DNA repair pathways that protect cells
against genomic damage. Disruption of this pathway can contribute to the development of …

Nucleotide excision repair (NER) is a multistep process that recognizes and eliminates a
wide spectrum of damage causing significant distortions in the DNA structure, such as UV …

Nucleotide excision repair (NER) is a versatile DNA repair pathway essential for the removal
of a broad spectrum of structurally diverse DNA lesions arising from a variety of sources …

Persistent dysregulation of the DNA damage response and repair in cells causes genomic
instability. The resulting genetic changes permit alterations in growth and proliferation …

As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved
in repair of helix-distorting DNA lesions, but the protein has also been implicated in several …

XPF‐ERCC 1 is a structure‐specific endonuclease pivotal for several DNA repair pathways
and, when mutated, can cause multiple diseases. Although the disease‐specific mutations …