Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and
accounts for the third-leading cause of cancer-related deaths. Over the past decades …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

Aberrantly expressed microRNAs (miRNAs) are involved in breast tumorigenesis. It is still
unclear if and how miRNAs-221/222 are implicated in breast cancer and the resistance to …

Chemotherapy-related cognitive impairment (CRCI) or “chemo brain” is a devastating
neurotoxic sequela of cancer-related treatments, especially for the elderly individuals. Here …

Protein tyrosine phosphatases (PTPs) play an important role in regulating cell signaling
events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival …

Protein tyrosine phosphorylation, which plays a vital role in a variety of human cellular
processes, is coordinated by protein tyrosine kinases and protein tyrosine phosphatases …

The protein tyrosine phosphatase (PTP) family is involved in multiple cellular functions and
plays an important role in various pathological and physiological processes. In many chronic …

Protein tyrosine phosphorylation is critical for proper function of cells and organisms.
Phosphorylation is regulated by the concerted but generically opposing activities of tyrosine …

As a member of protein tyrosine phosphatases (PTPs), the protein tyrosine phosphatase
receptor type O (PTPRO) has attracted increasing attention for its important roles in cell …