The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …

Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …

TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

Acidosis, a common characteristic of the tumor microenvironment, is associated with
alterations in metabolic preferences of cancer cells and progression of the disease. Here we …

The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

Alveolar macrophages (AMs) derive from fetal liver monocytes, which colonize the lung
during embryonic development and give rise to fully mature AMs perinatally. AM …

The bioavailability of members of the transforming growth factor β (TGF-β) family is
controlled by a number of mechanisms. Bona fide TGF-β is sequestered into the matrix in a …

The cytokine TGF-β plays an integral role in regulating immune responses. TGF-β has
pleiotropic effects on adaptive immunity, especially in the regulation of effector and …

Genetic studies in animals and humans indicate that gene mutations that functionally perturb
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …

Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with
global inhibitors of TGF-β have been disappointing, suggesting that a more targeted …