1, 2, 3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

Z Xu, SJ Zhao, Y Liu - European journal of medicinal chemistry, 2019 - Elsevier
Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …

Chalcone derivatives and their antibacterial activities: Current development

M Xu, P Wu, F Shen, J Ji, KP Rakesh - Bioorganic Chemistry, 2019 - Elsevier
The increase in antibiotic resistance due to various factors has encouraged the look for
novel compounds which are active against multidrug-resistant pathogens. In this framework …

Recent accomplishments on the synthetic/biological facets of pharmacologically active 1H-1, 2, 3-triazoles

S Kumar, B Sharma, V Mehra, V Kumar - European Journal of Medicinal …, 2021 - Elsevier
The continuous demand of medicinally important scaffolds has prompted the synthetic
chemists to identify simple and efficient routes for their synthesis. 1H-1, 2, 3-triazole …

Recent advances in isatin hybrids as potential anticancer agents

Z Ding, M Zhou, C Zeng - Archiv der Pharmazie, 2020 - Wiley Online Library
The isatin framework is a useful template for the development of novel anticancer agents.
This is exemplified by the fact that several isatin‐based anticancer agents, such as …

A mini review on pharmacological significance of isatin-1, 2, 3-triazole hybrids

A Kumar, Y Rohila, V Kumar… - Current Topics in Medicinal …, 2023 - ingentaconnect.com
Molecular hybridization is one of the recent stratagems in medicinal chemistry to synthesize
a novel hybrid molecule having better affinity and efficacy by combining two or more …

Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability

SK Ihmaid, SY Alraqa, MR Aouad, A Aljuhani… - Bioorganic …, 2021 - Elsevier
This study reports an efficient and convenient click chemistry synthesis of a novel series of
phthalimide scaffold linked to 1, 2, 3 triazole ring and terminal lipophilic fragments …

Isatin–azole hybrids and their anticancer activities

Y Hou, C Shang, H Wang, J Yun - Archiv der Pharmazie, 2020 - Wiley Online Library
Isatin and azole moieties, which have the ability to form various noncovalent interactions
with different therapeutic targets, are common pharmacophores in drug development. Isatin …

Design, click synthesis, anticancer screening and docking studies of novel benzothiazole-1, 2, 3-triazoles appended with some bioactive benzofused heterocycles

MR Aouad, MA Almehmadi, N Rezki, FF Al-blewi… - Journal of Molecular …, 2019 - Elsevier
Abstract New series of benzothiazole-1, 2, 3-triazoles; appended with benzothiazole, isatin
and/or benzimidazole moiety; were designed and synthesized through the click chemistry …

1, 2, 3-triazole derivatives with anti-breast cancer potential

X Wu, J Wang, S Xia, S Cheng… - Current Topics in …, 2022 - ingentaconnect.com
Breast cancer is one of the most prevalent malignant diseases, and one of the main causes
of mortality among women across the world. Despite advances in chemotherapy, drug …

N-1, 2, 3-Triazole–isatin derivatives: anti-proliferation effects and target identification in solid tumour cell lines

N Busto, J Leitão-Castro, AT García-Sosa… - RSC Medicinal …, 2022 - pubs.rsc.org
Molecular hybridization approaches have become an important strategy in medicinal
chemistry, and to this end, we have developed a series of novel N-1, 2, 3-triazole–isatin …