In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …

Dopamine is a prototypical neuromodulator that controls circuit function through G protein-
coupled receptor signalling. Neuromodulators are volume transmitters, with release followed …

Striatal dopamine and acetylcholine are essential for the selection and reinforcement of
motor actions and decision-making. In vitro studies have revealed an intrastriatal circuit in …

Dopamine neurons are characterized by their response to unexpected rewards, but they
also fire during movement and aversive stimuli. Dopamine neuron diversity has been …

To facilitate scalable profiling of single cells, we developed split-pool ligation-based
transcriptome sequencing (SPLiT-seq), a single-cell RNA-seq (scRNA-seq) method that …

External rewards such as food and money are potent modifiers of behaviour,. Pioneering
studies established that these salient sensory stimuli briefly interrupt the tonic discharge of …

There is increased appreciation that dopamine neurons in the midbrain respond not only to
reward and reward-predicting cues,, but also to other variables such as the distance to …

A full understanding of Parkinson's Disease etiopathogenesis and of the causes of the
preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A …

Pleasure is mediated by well-developed mesocorticolimbic circuitry and serves adaptive
functions. In affective disorders, anhedonia (lack of pleasure) or dysphoria (negative affect) …

Dopaminergic projection axons from the midbrain to the striatum are crucial for motor
control, as their degeneration in Parkinson disease results in profound movement deficits …