Migraine is a complex neurological disease with a genetic background. Headache is the
most prominent and clinically important symptom of migraine but its origin is still enigmatic …

Migraine stands as one of the most disabling neurological conditions worldwide. It is a
disorder of great challenge to study given its heterogeneous representation, cyclic nature …

Objectives.—To model, in rats, the development of chronic trigeminal nociceptive
hypersensitivity seen in patients with recurrent headache. Background.—Pathophysiology …

Calcitonin gene‐related peptide (CGRP) and metabolic products of nitric oxide (NO) are
increased in jugular venous plasma during migraine attacks and other primary headaches …

Animal models of human disease have been extremely helpful both in advancing the
understanding of brain disorders and in developing new therapeutic approaches. Models for …

Migraine is a common disabling neurological disorder with a serious socio-economical
burden. By blocking cyclooxygenase nonsteroidal anti-inflammatory drugs (NSAIDs) …

Pituitary adenylate cyclase activating polypeptide (PACAP) is present in the cranial arteries
and trigeminal sensory neurons. We therefore examined the alterations in PACAP-like …

Nitric oxide is one of the endogenous molecules that play a key role in migraine. However,
the interaction between NO and the main players in the nociceptive activity of the meningeal …

Sumatriptan, a relatively hydrophilic triptan, based on several animal studies has been
regarded to be unable to cross the blood–brain barrier (BBB). In more recent animal studies …

Background Trigeminal sensitization represents a major mechanism underlying migraine
attacks and their recurrence. Nitroglycerin (NTG) administration provokes spontaneous …