Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

Catalytic transformation of ubiquitous C–H bonds into valuable C–N bonds offers an efficient
synthetic approach to construct N-functionalized molecules. Over the last few decades …

Aliphatic allylic amines are found in a great variety of complex and biorelevant molecules.
The direct allylic C–H amination of alkenes serves as the most straightforward method …

The development of new methods for the direct functionalization of unactivated C–H bonds
is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic …

This Review summarizes advances in fluorination by C (sp2)− H and C (sp3)− H activation.
Transition‐metal‐catalyzed approaches championed by palladium have allowed the …

Although they offer great potentials, the high reactivity and diverse pathways of radical
chemistry pose difficult problems for applications in organic synthesis. In addition to the …

Palladium-catalyzed aerobic oxidation reactions have been the focus of industrial
application and extensive research efforts for nearly 60 years. A significant transition …

Over the last decade, substantial research has led to the introduction of an impressive
number of efficient procedures which allow the selective construction of C C bonds by …

The direct functionalization of C H bonds in organic compounds has recently emerged as a
powerful and ideal method for the formation of carbon–carbon and carbon–heteroatom …

Functionalizing traditionally inert carbon–hydrogen bonds represents a powerful
transformation in organic synthesis, providing new entries to valuable structural motifs and …