Systemic inflammation can be triggered by infection, surgery, trauma or burns. During
systemic inflammation, an overshooting immune response induces tissue damage resulting …

Sepsis, a life threating syndrome characterized by organ failure after infection, is the most
common cause of death in hospitalized patients. The treatment of sepsis is generally …

Purpose Investigate safety and tolerability of adrecizumab, a humanized monoclonal
adrenomedullin antibody, in septic shock patients with high adrenomedullin. Methods Phase …

Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …

Sepsis remains a major medical challenge, for which, apart from improvements in supportive
care, treatment has not relevantly changed over the last few decades. Vasodilation and …

Background Secretion of adrenomedullin (ADM) is stimulated by volume overload to
maintain endothelial barrier function, and higher levels of biologically active (bio‐) ADM in …

Sepsis remains a major scientific and medical challenge, for which, apart from significant
refinements in supportive therapy, treatment has barely changed over the last few decades …

Adrenomedullin (AM) is a vasodilative peptide with various physiological functions,
including the maintenance of vascular tone and endothelial barrier function. AM levels are …

Sepsis is associated with high rates of mortality in the intensive care unit and accompanied
by systemic inflammatory reactions, secondary infections, and multiple organ failure …

It is evident that the admission of some patients with sepsis and septic shock to hospitals is
occurring late in their illness, which has contributed to the increase in poor outcomes and …