Molecular, subcellular, and arrhythmogenic mechanisms in genetic RyR2 disease
ED Fowler, S Zissimopoulos - Biomolecules, 2022 - mdpi.com
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …
[HTML][HTML] Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models
The mouse is the second mammalian species, after the human, in which substantial amount
of the genomic information has been analyzed. With advances in transgenic technology …
of the genomic information has been analyzed. With advances in transgenic technology …
Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS
Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen
species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic …
species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic …
An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular …
Background: Genetic variants in calsequestrin-2 (CASQ2) cause an autosomal recessive
form of catecholaminergic polymorphic ventricular tachycardia (CPVT), although isolated …
form of catecholaminergic polymorphic ventricular tachycardia (CPVT), although isolated …
Evaluation of changes in morphology and function of human induced pluripotent stem cell derived cardiomyocytes (HiPSC-CMs) cultured on an aligned-nanofiber …
Introduction Dilated cardiomyopathy is a major cause of progressive heart failure. Utilization
of stem cell therapy offers a potential means of regenerating viable cardiac tissue. However …
of stem cell therapy offers a potential means of regenerating viable cardiac tissue. However …
Superresolution modeling of calcium release in the heart
MA Walker, GSB Williams, T Kohl, SE Lehnart… - Biophysical …, 2014 - cell.com
Stable calcium-induced calcium release (CICR) is critical for maintaining normal cellular
contraction during cardiac excitation-contraction coupling. The fundamental element of …
contraction during cardiac excitation-contraction coupling. The fundamental element of …
Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by …
In a physiological setting, mitochondria increase oxidative phosphorylation during periods of
stress to meet increased metabolic demand. This in part is mediated via enhanced …
stress to meet increased metabolic demand. This in part is mediated via enhanced …
[HTML][HTML] Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation–remodeled hearts
T Liu, F Xiong, XY Qi, J Xiao, L Villeneuve, I Abu-Taha… - JCI insight, 2020 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca 2+ handling, promoting ectopic
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …
MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca2+ release in hypertrophic rat cardiomyocytes
Cardiac dysfunction in heart failure (HF) and diabetic cardiomyopathy (DCM) is associated
with aberrant intracellular Ca2+ handling and impaired mitochondrial function accompanied …
with aberrant intracellular Ca2+ handling and impaired mitochondrial function accompanied …
Proarrhythmic remodeling of calcium homeostasis in cardiac disease; implications for diabetes and obesity
S Hamilton, D Terentyev - Frontiers in physiology, 2018 - frontiersin.org
A rapid growth in the incidence of diabetes and obesity has transpired to a major heath
issue and economic burden in the postindustrial world, with more than 29 million patients …
issue and economic burden in the postindustrial world, with more than 29 million patients …