Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

The senescence programme is implicated in diverse biological processes, including
embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing. Although in vivo …

Patients with chronic kidney disease (CKD) have elevated circulating levels of
trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with …

Fibroblast growth factor (FGF) 23 is a phosphaturic hormone whose physiologic actions on
target tissues are mediated by FGF receptors (FGFR) and klotho, which functions as a co …

Associations between chronic kidney disease (CKD) and the gut microbiota have been
postulated, yet questions remain about the underlying mechanisms. In humans, dietary …

The high serum fibroblast growth factor 23 (FGF23) levels in patients with acute kidney injury
(AKI) and chronic kidney disease (CKD) are associated with increased morbidity and …

Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery
disease (PAD). While solutes retained in CKD patients (uremic solutes) inflict vascular …

Klotho acts as a co-receptor for and dictates tissue specificity of circulating FGF23. FGF23
inhibits PTH secretion, and reduced Klotho abundance is considered a pathogenic factor in …

Chronic kidney disease (CKD) causes cognitive impairment and contributes to the overall
global burden of dementia. However, mechanisms through which the kidneys and brain …

Background Erythropoietin (EPO) has been reported as a novel determinant of fibroblast
growth factor 23 (FGF23) production; however, it is unknown whether FGF23 is stimulated by …