Knowledge of age sensitivity, the capacity of a behavioral test to reliably detect age-related
changes, has utility in the design of experiments to elucidate processes of normal aging. We …

Ataxic mutant mice can be used to represent models of cerebellar degenerative disorders.
They serve for investigation of cerebellar function, pathogenesis of degenerative processes …

The rotarod test is widely used to evaluate the motor coordination of rodents, and is
especially sensitive in detecting cerebellar dysfunction. However, mice with striatal …

Dysregulation of early neurodevelopment is implicated in macrocephaly/autism disorders.
However, the mechanism underlying this dysregulation, particularly in human cells, remains …

Huntington's disease (HD) is an adult-onset neurodegenerative disorder involving motor
dysfunction, cognitive deficits, and psychiatric disturbances that result from underlying …

Retinoid-related orphan receptor α (RORα) is a member of the nuclear receptor superfamily.
To study its physiological role we generated null-mutant mice by targeted insertion of a lacZ …

The transcriptional properties of unliganded thyroid hormone receptors are thought to cause
the misdevelopment during hypothyroidism of several functions essential for adult life. To …

Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease, and its incidence is predicted to increase worldwide. Striatal dopamine …

It is now widely accepted that hippocampal neurogenesis underpins critical cognitive
functions, such as learning and memory. To assess the behavioral importance of adult-born …

Tonic inhibition in the brain is mediated through an activation of extrasynaptic GABAA
receptors by the tonically released GABA, resulting in a persistent GABAergic inhibitory …