Spinal electrical stimulation to improve sympathetic autonomic functions needed for movement and exercise after spinal cord injury: a scoping clinical review

S Flett, J Garcia, KC Cowley - Journal of Neurophysiology, 2022 - journals.physiology.org
Spinal cord injury (SCI) results in sensory, motor, and autonomic dysfunction. Obesity,
cardiovascular disease, and metabolic disease are highly prevalent after SCI. Although …

The plasticity of nerve fibers: The prolonged effects of polarization of afferent fibers

E Jankowska, I Hammar - Journal of Neurophysiology, 2021 - journals.physiology.org
The review surveys various aspects of the plasticity of nerve fibers, in particular the
prolonged increase in their excitability evoked by polarization, focusing on a long-lasting …

GABA facilitates spike propagation through branch points of sensory axons in the spinal cord

K Hari, AM Lucas-Osma, K Metz, S Lin, N Pardell… - Nature …, 2022 - nature.com
Movement and posture depend on sensory feedback that is regulated by specialized
GABAergic neurons (GAD2+) that form axo-axonic contacts onto myelinated proprioceptive …

Locomotor-related propriospinal V3 neurons produce primary afferent depolarization and modulate sensory transmission to motoneurons

S Lin, K Hari, S Black, A Khatmi… - Journal of …, 2023 - journals.physiology.org
When a muscle is stretched, sensory feedback not only causes reflexes but also leads to a
depolarization of sensory afferents throughout the spinal cord (primary afferent …

The structure of sensory afferent compartments in health and disease

SJ Middleton, J Perez‐Sanchez… - Journal of Anatomy, 2022 - Wiley Online Library
Primary sensory neurons are a heterogeneous population of cells able to respond to both
innocuous and noxious stimuli. Like most neurons they are highly compartmentalised …

Modulation of sensory input to the spinal cord: Contribution of focal epidural polarization and of GABA released by interneurons and glial cells

I Hammar, E Jankowska - European Journal of Neuroscience, 2024 - Wiley Online Library
Modulation of input from primary afferent fibres has long been examined at the level of the
first relays of these fibres. However, recent studies reveal that input to the spinal cord may …

Differential Effects of Invasive Anodal Trans-spinal Direct Current Stimulation on Monosynaptic Excitatory Postsynaptic Potentials, Ia Afferents Excitability, and …

T Jankowiak, M Cholewiński, M Bączyk - Neuroscience, 2022 - Elsevier
In presymptomatic amyotrophic lateral sclerosis (ALS), spinal motoneurons (MNs) have
reduced firing patterns and synaptic excitation levels. Preliminary data indicated that in the …

Is there hope that transpinal direct current stimulation corrects motoneuron excitability and provides neuroprotection in amyotrophic lateral sclerosis?

M Bączyk, P Krutki, D Zytnicki - Physiological Reports, 2021 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of largely unknown
pathophysiology, characterized by the progressive loss of motoneurons (MNs). We review …

Do long‐lasting effects of epidural polarization of afferent fibres depend on persistent sodium current?

D Kaczmarek, E Jankowska - European Journal of …, 2023 - Wiley Online Library
Few attempts have so far been made to define the mechanisms underlying the hour‐long
effects of trans‐spinal stimulation combined with epidural polarization. In the present study …

[HTML][HTML] Spinal Networks and Spinal Cord Injury: A Tribute to Reggie Edgerton: Spinal electrical stimulation to improve sympathetic autonomic functions needed for …

S Flett, J Garcia, KC Cowley - Journal of Neurophysiology, 2022 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) results in sensory, motor, and autonomic dysfunction. Obesity,
cardiovascular disease, and metabolic disease are highly prevalent after SCI. Although …