The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed chanzyme that possesses an ion channel permeable to the divalent cations …

Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

Abstract Aims Transient Receptor Potential Melastatin 7 (TRPM7) cation channel is a
chanzyme (channel+ kinase) that influences cellular Mg2+ homeostasis and vascular …

Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na+, K+,
and Mg2+ dysregulation. Owing to its steroidal structure, aldosterone is an active …

Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1,
PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the …

Hypomagnesaemia is a common feature of renal Na+ wasting disorders such as Gitelman
and EAST/SeSAME syndrome. These genetic defects specifically affect Na+ reabsorption in …

TRPM (transient receptor potential melastatin) 7, a member of the TRPM subfamily, is a
nonselective cation channel located on the cell membrane that regulates mammalian cell …

Transient receptor potential (TRP) channels are remarkable transmembrane protein
complexes that are essential for the physiology of the tissues in which they are expressed …

Recent studies showed that both prostaglandin E2 (PGE 2) and transient receptor potential
melastatin 7 (TRPM 7) play important roles in migration and proliferation of human …

Abstract Na+–K+–2Cl− Cotransporter (NKCC1) is a protein that aids in the active transport of
sodium, potassium, and chloride ions across cell membranes. It has been shown that long …