Copper-transporting ATPases (Cu-ATPases) ATP7A and ATP7B are evolutionarily
conserved polytopic membrane proteins with essential roles in human physiology. The Cu …

P 1B-ATPases form a distinct evolutionary sub-family of P-type ATPases, transporting
transition metals such as Cu, Zn, Cd, Pb and Co across membranes in a wide range of …

The trace metal copper is essential for a variety of biological processes, but extremely toxic
when present in excessive amounts. Therefore, concentrations of this metal in the body are …

P 1B-type ATPases transport heavy metals (Cu+, Cu 2+, Zn 2+, Co 2+, Cd 2+, Pb 2+) across
membranes. Present in most organisms, they are key elements for metal homeostasis. P 1B …

Wilson disease is an autosomal recessive inherited disorder of copper metabolism. The
Wilson disease gene codes for a copper transporting P-type ATPase (ATP7B). Molecular …

Wilson disease is a severe genetic disorder associated with intracellular copper overload.
The affected gene, ATP7B, has been identified, but the molecular events leading to Wilson …

Background & Aims The earliest characteristic alterations of the liver pathology in Wilson
disease (WD) include steatosis, which is sometimes indistinguishable from non-alcoholic …

Wilson disease (WD) is an autosomal recessive copper overload disorder of the liver and
basal ganglia. WD is caused by mutations in the gene encoding ATP7B, a protein localized …

Wilson disease (WND) is a disorder of copper transport resulting in copper accumulation in
liver, kidney, and brain. This recessive disorder expresses variable clinical symptoms …

Wilson disease protein (ATP7B) is a copper-transporting P1B-type ATPase that regulates
copper homeostasis and biosynthesis of copper-containing enzymes in human tissues …