Naturally occurring biological macromolecules-based hydrogels: Potential biomaterials for peripheral nerve regeneration

H Samadian, H Maleki, A Fathollahi, M Salehi… - International journal of …, 2020 - Elsevier
Despite the recent advances in the treatment strategies of peripheral nerve system defects,
peripheral nerve injury (PNI) is still one of the most important health issues with increasing …

Design of hydrogel-based scaffolds for the treatment of spinal cord injuries

N Ghane, MH Beigi, S Labbaf… - Journal of Materials …, 2020 - pubs.rsc.org
Spinal cord injury (SCI) is a traumatic lesion that diminishes sensory and/or motor neuronal
functionality, directly affecting the quality of the patient's life. Due to the central nervous …

Rapid continuous 3D printing of customizable peripheral nerve guidance conduits

W Zhu, KR Tringale, SA Woller, S You, S Johnson… - Materials Today, 2018 - Elsevier
Engineered nerve guidance conduits (NGCs) have been demonstrated for repairing
peripheral nerve injuries. However, there remains a need for an advanced biofabrication …

Adaptable microporous hydrogels of propagating NGF‐gradient by injectable building blocks for accelerated axonal outgrowth

RS Hsu, PY Chen, JH Fang, YY Chen… - Advanced …, 2019 - Wiley Online Library
Injectable hydrogels in regeneration medicine can potentially mimic hierarchical natural
living tissue and fill complexly shaped defects with minimally invasive implantation …

Effects of konjac glucomannan on the structure, properties, and drug release characteristics of agarose hydrogels

Y Yuan, L Wang, RJ Mu, J Gong, Y Wang, Y Li… - Carbohydrate …, 2018 - Elsevier
Pure agarose (AG) hydrogels have strong rigidity and brittleness, which greatly limit their
applications. Therefore, in this study, konjac glucomannan (KGM) was used to improve the …

Hydrogel, electrospun and composite materials for bone/cartilage and neural tissue engineering

B Niemczyk-Soczynska, A Zaszczyńska, K Zabielski… - Materials, 2021 - mdpi.com
Injuries of the bone/cartilage and central nervous system are still a serious socio-economic
problem. They are an effect of diversified, difficult-to-access tissue structures as well as …

Engineered Schwann cell-based therapies for injury peripheral nerve reconstruction

Q Su, MI Nasser, J He, G Deng, Q Ouyang… - Frontiers in Cellular …, 2022 - frontiersin.org
Compared with the central nervous system, the adult peripheral nervous system possesses
a remarkable regenerative capacity, which is due to the strong plasticity of Schwann cells …

Chitosan-based nerve guidance conduit with microchannels and nanofibers promotes schwann cells migration and neurite growth

G Zhou, Y Chen, F Dai, X Yu - Colloids and Surfaces B: Biointerfaces, 2023 - Elsevier
Peripheral nerve injury (PNI) is the leading cause of permanent dysfunction in movement
and sensation. Despite the rapid development of tissue engineering in peripheral nerve …

Matching mechanical heterogeneity of the native spinal cord augments axon infiltration in 3D-printed scaffolds

KA Tran, BJ DeOre, D Ikejiani, K Means, LS Paone… - Biomaterials, 2023 - Elsevier
Scaffolds delivered to injured spinal cords to stimulate axon connectivity often match the
anisotropy of native tissue using guidance cues along the rostral-caudal axis, but current …

Microstructure and in vivo characterization of multi-channel nerve guidance scaffolds

KM Pawelec, J Koffler, D Shahriari, A Galvan… - Biomedical …, 2018 - iopscience.iop.org
In a previous study, we demonstrated a novel manufacturing approach to fabricate multi-
channel scaffolds (MCS) for use in spinal cord injuries (SCI). In the present study, we …