Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis

S Garcia-Recio, T Hinoue, GL Wheeler, BJ Kelly… - Nature Cancer, 2023 - nature.com
Abstract The AURORA US Metastasis Project was established with the goal to identify
molecular features associated with metastasis. We assayed 55 females with metastatic …

Improving brain tumor classification performance with an effective approach based on new deep learning model named 3ACL from 3D MRI data

F Demir, Y Akbulut, B Taşcı, K Demir - Biomedical Signal Processing and …, 2023 - Elsevier
Many machine learning-based studies have been carried out in the literature for the
detection of brain tumors using MRI data and most of what has been done in the last 6 years …

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

C Monteiro, L Miarka, M Perea-García, N Priego… - Nature medicine, 2022 - nature.com
Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain
metastasis; however, its efficacy in preventing disease progression and the associated …

Fatty acid synthase: a druggable driver of breast cancer brain metastasis

JA Menendez, R Lupu - Expert opinion on therapeutic targets, 2022 - Taylor & Francis
ABSTRACT Introduction Brain metastasis (BrM) is a key contributor to morbidity and
mortality in breast cancer patients, especially among high-risk epidermal growth factor …

From immunohistochemistry to new digital ecosystems: a state-of-the-art biomarker review for precision breast cancer medicine

SM Hacking, E Yakirevich, Y Wang - Cancers, 2022 - mdpi.com
Simple Summary In this state-of-the-art breast biomarker review, we have tried to imagine
and illustrate future, emerging digital breast cancer ecosystems which allow for greater …

Immunogenomic analysis of human brain metastases reveals diverse immune landscapes across genetically distinct tumors

ÁF Álvarez-Prado, RR Maas, K Soukup, F Klemm… - Cell Reports …, 2023 - cell.com
Brain metastases (BrMs) are the most common form of brain tumors in adults and frequently
originate from lung and breast primary cancers. BrMs are associated with high mortality …

Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity

S Prekovic, T Chalkiadakis, M Roest… - EMBO Molecular …, 2023 - embopress.org
Glucocorticoid receptor (GR) is a transcription factor that plays a crucial role in cancer
biology. In this study, we utilized an in silico‐designed GR activity signature to demonstrate …

Three-Dimensional Visualization of Breast Cancer Pathology Evolution in Clinical Patient Tissues with NIR-II Imaging

S Li, Q Xin, Y Li, H Ma, H Yan, S Ao, H Li, Q Wang… - Nano Letters, 2024 - ACS Publications
Breast cancer (BC) is the most common tumor worldwide and requires crucial molecular
typing for treatment and prognosis assessment. Currently, approaches like pathological …

[HTML][HTML] Pan-cancer molecular subtypes of metastasis reveal distinct and evolving transcriptional programs

Y Zhang, F Chen, CJ Creighton - Cell Reports Medicine, 2023 - cell.com
Molecular mechanisms underlying cancer metastasis span diverse tissues of origin. Here,
we synthesize and collate the transcriptomes of patient-derived xenografts and patient tumor …

circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer

Y Zhang, Y Tan, J Yuan, H Tang, H Zhang, Y Tang… - Cancer Letters, 2024 - Elsevier
Cancer metastasis is the major cause of death in patients with breast cancer (BC). The liver
is a common site of breast cancer metastasis, and the 5-year survival rate of patients with …