The roles of FLOT1 in human diseases

Z Zhan, M Ye, X Jin - Molecular Medicine Reports, 2023 - spandidos-publications.com
FLOT1, a scaffold protein of lipid rafts, is involved in several biological processes, including
lipid raft protein‑dependent or clathrin‑independent endocytosis, and the formation of …

Serotonin Signaling through Lipid Membranes

LS Kalinichenko, J Kornhuber, S Sinning… - ACS Chemical …, 2024 - ACS Publications
Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …

Paternal immune activation by poly I: C modulates sperm noncoding RNA profiles and causes transgenerational changes in offspring behavior

EA Kleeman, SN Reisinger, P Adithya… - Brain, Behavior, and …, 2024 - Elsevier
Paternal pre-conceptual environmental experiences, such as stress and diet, can affect
offspring brain and behavioral phenotypes via epigenetic modifications in sperm …

Serotonin-releasing agents with reduced off-target effects

FP Mayer, M Niello, D Cintulova, S Sideromenos… - Molecular …, 2023 - nature.com
Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of
depression and anxiety-related disorders, eg, social phobias and post-traumatic stress …

Proteomic profile of the hard corona of charged polystyrene nanoparticles exposed to sea urchin Paracentrotus lividus coelomic fluid highlights potential drivers of …

G Grassi, C Landi, C Della Torre, E Bergami… - Environmental science …, 2019 - pubs.rsc.org
Polystyrene nanoparticles (PS NPs) are considered an upcoming threat to marine
ecosystems. When NPs encounter biological fluids, they are readily covered by a …

Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder

J Zhong, S Li, W Zeng, X Li, C Gu, J Liu… - …, 2019 - nature.com
Major depressive disorder (MDD) is the most prevalent mental disorder that affects more
than 200 million people worldwide. Recent large-scale genome-wide association studies …

The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma

F Koban, M Freissmuth - EMBO reports, 2023 - embopress.org
Monoamine transporters retrieve serotonin (SERT), dopamine (DAT), and norepinephrine
(NET) from the synaptic cleft. Transporter internalization contributes to the regulation of their …

Multi-context genetic modeling of transcriptional regulation resolves novel disease loci

M Thompson, MG Gordon, A Lu, A Tandon… - Nature …, 2022 - nature.com
A majority of the variants identified in genome-wide association studies fall in non-coding
regions of the genome, indicating their mechanism of impact is mediated via gene …

Uncoupling protein-1 modulates anxiety-like behavior in a temperature-dependent manner

S Sideromenos, A Gundacker, M Nikou… - Journal of …, 2022 - Soc Neuroscience
A strong bidirectional link between metabolic and psychiatric disorders exists; yet, the
molecular basis underlying this interaction remains unresolved. Here we explored the role of …

STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology

SN Reisinger, S Sideromenos, O Horvath… - Molecular …, 2021 - nature.com
The signal transducer and activator of transcription 3 (STAT3) signalling pathway is
activated through phosphorylation by Janus kinases in response to a diverse set of …