Profiling the immune response to periprosthetic joint infection and non-infectious arthroplasty failure

CR Fisher, R Patel - Antibiotics, 2023 - mdpi.com
Arthroplasty failure is a major complication of joint replacement surgery. It can be caused by
periprosthetic joint infection (PJI) or non-infectious etiologies, and often requires surgical …

Synovial C-reactive protein is a useful adjunct for diagnosis of periprosthetic joint infection

CM Baker, GS Goh, S Tarabichi, N Shohat… - The Journal of …, 2022 - Elsevier
Background The diagnostic utility of synovial C-reactive protein (CRP) has been debated for
a while. Existing studies are limited by small sample sizes and using outdated criteria for …

Blood and synovial fluid calprotectin as biomarkers to diagnose chronic hip and knee periprosthetic joint infections

D Grzelecki, P Walczak, M Szostek… - The bone & joint …, 2021 - boneandjoint.org.uk
Aims Calprotectin (CLP) is produced in neutrophils and monocytes and released into body
fluids as a result of inflammation or infection. The aim of this study was to evaluate the utility …

Synovial fluid α defensin has comparable accuracy to synovial fluid white blood cell count and polymorphonuclear percentage for periprosthetic joint infection …

MI Ivy, K Sharma… - The bone & joint …, 2021 - boneandjoint.org.uk
Aims The aim of this study was to determine the diagnostic accuracy of α defensin (AD)
lateral flow assay (LFA) and enzyme-linked immunosorbent assay (ELISA) tests for …

Synovial fluid biomarkers for the diagnosis of periprosthetic joint infection—a systematic review and meta-analysis of their diagnostic accuracy according to different …

JS Vale, FS Castelo, BS Barros, AC Ribau… - The Journal of …, 2023 - Elsevier
Background Different synovial fluid biomarkers have emerged to improve periprosthetic joint
infection (PJI) diagnosis. The goals of this paper were (i) to assess their diagnostic accuracy …

The accuracy of D-dimer in the diagnosis of periprosthetic infections: a systematic review and meta-analysis

R Wang, H Zhang, P Ding, Q Jiao - Journal of Orthopaedic Surgery and …, 2022 - Springer
Background Periprosthetic joint infection (PJI) is a devastating complication after total hip
arthroplasty (THA) or total knee arthroplasty (TKA). It is scarce and contradicting evidence …

Current relevance of biomarkers in diagnosis of periprosthetic joint infection: an update

S Tripathi, S Tarabichi, J Parvizi, A Rajgopal - Arthroplasty, 2023 - Springer
With a significant rise in the number of arthroplasty procedures performed worldwide, the
increasing revision burden posed by periprosthetic joint infection (PJI) is a matter of growing …

Reliability of synovial fluid alpha-defensin and leukocyte esterase in diagnosing periprosthetic joint infection (PJI): a systematic review and meta-analysis

Y Chen, X Kang, J Tao, Y Zhang, C Ying… - Journal of Orthopaedic …, 2019 - Springer
Background Synovial fluid proteins had been applied as diagnostic biomarkers for
periprosthetic joint infection (PJI) in recent research papers. Thus, this meta-analysis aimed …

Reliable Diagnostic Tests and Thresholds for Preoperative Diagnosis of Non‐Inflammatory Arthritis Periprosthetic Joint Infection: A Meta‐analysis and Systematic …

H Tang, J Xu, W Yuan, Y Wang, B Yue… - Orthopaedic …, 2022 - Wiley Online Library
Objective The current diagnostic criteria for periprosthetic joint infection (PJI) are diverse and
controversial, leading to delayed diagnosis. This study aimed to evaluate and unify their …

Does the alpha defensin ELISA test perform better than the alpha defensin lateral flow test for PJI diagnosis? A systematic review and meta-analysis of prospective …

JWP Kuiper, SJ Verberne, SJ Vos… - … and Related Research …, 2020 - journals.lww.com
Background Periprosthetic joint infection (PJI) following total joint arthroplasty is a serious
complication that causes severe morbidity and adds a major financial burden to the …