Autosomal dominant polycystic kidney disease, autosomal recessive polycystic kidney
disease, and nephronophthisis are hereditary disorders with the occurrence of numerous …

Genetic or hereditary kidney disease stands as a pivotal cause of chronic kidney disease
(CKD). The proliferation and widespread utilization of DNA testing in clinical settings have …

Renal cystic diseases (RCDs) can arise from utero to early adulthood and present with a
variety of symptoms including renal, hepatic, and cardiovascular manifestations. It is well …

Background: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and is highly
metastatic. Our prior studies have demonstrated the critical role of axon guidance pathway …

Aim Technological advances and increased access have led to genomics expanding
beyond the genetics clinic. Consequently, nephrologists can now order genomic testing for …

The nonmotile primary cilium is a sensory structure found on most mammalian cell types that
integrates multiple signaling pathways involved in tissue development and postnatal …

(1) Background: Autosomal recessive polycystic kidney disease (ARPKD) is a rare ciliopathy
characterized by progressively enlarged kidneys with fusiform dilatation of the collecting …

Protein ubiquitination is an enzymatic cascade reaction and serves as an important protein
post-translational modification (PTM) that is involved in the vast majority of cellular life …

Polycystic kidney disease (PKD) is an inherited disorder that results in large kidneys,
numerous fluid-filled cysts, and ultimately end-stage kidney disease. PKD is either …

Background: This study aims to report the clinical characteristics of a child with autosomal
recessive polycystic kidney disease (ARPKD) within a Chinese Zhuang ethnic family …