Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

Histone acetylation and deacetylation are important epigenetic mechanisms that regulate
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of …

Chemotherapy is one of the most established and effective treatments for almost all types of
cancer. However, the elevated toxicity due to the non-tumor-associated effects, development …

Histone deacetylase (HDAC) 6 is the best‐characterized class II b deacetylase that
regulates many important biological processes via the formation of complexes with its …

Microtubules have important functions ranging from maintenance of cell morphology to
subcellular transport, cellular signaling, cell migration, and formation of cell polarity. At the …

Histone deacetylase 6 (HDAC6), a member of the HDAC family whose major substrate is α‐
tubulin, has become a target for drug development to treat cancer due to its major …

Background HDAC6, a structurally and functionally distinct member of the HDAC family, is
an integral part of multiple cellular functions such as cell proliferation, apoptosis …

The nuclear factor‐κB (NF‐κB) pathway is a critical regulator of innate and adaptive
immunity. Noncanonical K63‐linked polyubiquitination plays a key regulatory role in NF‐κB …

Since its discovery forty years ago, protein ubiquitination has been an ever-expanding field.
Virtually all biological processes are controlled by the post-translational conjugation of …

Nuclear factor-kappa B (NF-κB) is a critical regulator of multiple biological functions
including innate and adaptive immunity and cell survival. Activation of NF-κB is tightly …