Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …

Currently, the concept of 'neuroinflammation'includes inflammation associated with
neurodegenerative diseases, in which there is little or no infiltration of blood-derived …

Reactive oxygen species are generated as a by-product of routine biochemical reactions.
However, dysfunction of the antioxidant system or mutations in gene function may result in …

Redox homeostasis is crucial for proper cellular functions, including receptor tyrosine kinase
signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a …

The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and
NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation …

Oxidative stress is a common hallmark of neuronal cell death associated with
neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as …

Oxidative damage is considered to be the primary cause of several aging associated
disease pathologies. Cumulative oxidative damage tends to be pervasive among cellular …

Background Aberrant accumulation of transition metals in the brain may have an early and
important role in the pathogenesis of several neurodegenerative disorders, including …

Huntington disease (HD) is a progressive neurodegenerative disorder caused by dominant
polyglutamine (polyQ) expansion within the N terminus of huntingtin (Htt) protein. Abnormal …