The impact of glucose-lowering drugs on sarcopenia in type 2 diabetes: current evidence and underlying mechanisms

E Massimino, A Izzo, G Riccardi, G Della Pepa - Cells, 2021 - mdpi.com
The age-related decrease in skeletal muscle mass together with the loss of muscle power
and function is defined sarcopenia. Mounting evidence suggests that the prevalence of …

Understanding the role of hyperglycemia and the molecular mechanism associated with diabetic neuropathy and possible therapeutic strategies

M Kaur, S Misra, P Swarnkar, P Patel, BD Kurmi… - Biochemical …, 2023 - Elsevier
Diabetic neuropathy is a neuro-degenerative disorder that encompasses numerous factors
that impact peripheral nerves in the context of diabetes mellitus (DM). Diabetic peripheral …

CGRP sensory neurons promote tissue healing via neutrophils and macrophages

YZ Lu, B Nayer, SK Singh, YK Alshoubaki, E Yuan… - Nature, 2024 - nature.com
The immune system has a critical role in orchestrating tissue healing. As a result,
regenerative strategies that control immune components have proved effective,. This is …

Associations of metabolic heterogeneity of obesity with frailty progression: Results from two prospective cohorts

D He, Y Qiu, M Yan, T Zhou, Z Cheng… - Journal of cachexia …, 2023 - Wiley Online Library
Background Previous studies indicated that obesity would accelerate frailty progression.
However, obesity is heterogeneous by different metabolic status. The associations of …

SGLT2 inhibitors: A novel therapy for cognitive impairment via multifaceted effects on the nervous system

J Mei, Y Li, L Niu, R Liang, M Tang, Q Cai, J Xu… - Translational …, 2024 - Springer
The rising prevalence of diabetes mellitus has casted a spotlight on one of its significant
sequelae: cognitive impairment. Sodium-glucose cotransporter-2 (SGLT2) inhibitors …

The role of adipose-derived stem cells-derived extracellular vesicles in the treatment of diabetic foot ulcer: trends and prospects

H Deng, Y Chen - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetic foot ulcer (DFU) is one of the most severe chronic complications of type 2 diabetes
mellitus, which is mainly caused by peripheral vascular occlusion with various degrees of …

One nervous system: critical links between central and peripheral nervous system health and implications for obesity and diabetes

KL Townsend - Diabetes, 2024 - diabetesjournals.org
There are key differences between the central nervous system (CNS)(brain and spinal cord)
and peripheral nervous system (PNS), such as glial cell types, whether there is protection by …

Hand and foot exercises for diabetic peripheral neuropathy: A randomized controlled trial

MMTM Win, K Fukai, HH Nyunt… - Nursing & Health …, 2020 - Wiley Online Library
Exercises for diabetic peripheral neuropathy remain controversial, especially with regard to
recommended precautions and weightbearing exercises for individuals. We aimed to …

Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients

M Nadi, E Bambaeichi, SM Marandi - … , Metabolic Syndrome and …, 2019 - Taylor & Francis
Introduction and aim The purpose of this study was to compare the effect of 12 weeks of low-
intensity resistance training and exercises for peripheral neuropathy (EPN) on the …

Peripheral neuropathy as a component of skeletal disease in diabetes

AT Beeve, JM Brazill, EL Scheller - Current Osteoporosis Reports, 2019 - Springer
Abstract Purpose of Review The goal of this review is to explore clinical associations
between peripheral neuropathy and diabetic bone disease and to discuss how nerve …