The rise of continuous flow biocatalysis–fundamentals, very recent developments and future perspectives

P De Santis, LE Meyer, S Kara - Reaction Chemistry & Engineering, 2020 - pubs.rsc.org
Biocatalysis community has witnessed a drastic increase in the number of studies for the use
of enzymes in continuously operated flow reactors. This significant interest arose from the …

New Trends and Future Opportunities in the Enzymatic Formation of C− C, C− N, and C− O bonds

JJ Sangster, JR Marshall, NJ Turner… - …, 2022 - Wiley Online Library
Organic chemistry provides society with fundamental products we use daily. Concerns about
the impact that the chemical industry has over the environment is propelling major changes …

Development of continuous flow systems to access secondary amines through previously incompatible biocatalytic cascades

AP Mattey, GJ Ford, J Citoler, C Baldwin… - Angewandte Chemie …, 2021 - Wiley Online Library
A key aim of biocatalysis is to mimic the ability of eukaryotic cells to carry out multistep
cascades in a controlled and selective way. As biocatalytic cascades get more complex …

Asymmetric Synthesis of N‐Substituted 1,2‐Amino Alcohols from Simple Aldehydes and Amines by One‐Pot Sequential Enzymatic Hydroxymethylation and …

Y Li, N Hu, Z Xu, Y Cui, J Feng, P Yao, Q Wu… - Angewandte …, 2022 - Wiley Online Library
Abstract The chiral N‐substituted 1, 2‐amino alcohol motif is found in many natural and
synthetic bioactive compounds. In this study, enzymatic asymmetric reductive amination of α …

Construction of chemoenzymatic linear cascades for the synthesis of chiral compounds

C Ascaso‐Alegre… - European Journal of …, 2022 - Wiley Online Library
Inspired by nature, synthetic chemists try to mimic the efficient metabolic networks in living
organisms to build complex molecules by combining different types of catalysts in the same …

What's new in flow biocatalysis? A snapshot of 2020–2022

M Crotti, MS Robescu, JM Bolivar, D Ubiali… - Frontiers in …, 2023 - frontiersin.org
Flow biocatalysis is a key enabling technology that is increasingly being applied to a wide
array of reactions with the aim of achieving process intensification, better control of …

Reaching new biocatalytic reactivity using continuous flow reactors

SC Cosgrove, AP Mattey - Chemistry–A European Journal, 2022 - Wiley Online Library
The use of flow reactors in biocatalysis has increased significantly in recent years. Chemists
have begun to design flow systems that even allow new biocatalytic reactions to take place …

Application of a statistical approach to process development of futibatinib by employing quality-by-design principles. Part 1: identification of critical process parameters …

Y Abe, K Emori - Organic Process Research & Development, 2022 - ACS Publications
We focus on a novel experimental design and statistical analysis to identify the critical
process parameters (CPPs) of impurities in futibatinib, which is a fibroblast growth factor …

One‐pot Heterogeneous Biocatalysis under Thermal Decay for Fructose Production from Lactose using Co‐Immobilized Enzymes: Modeling and Simulation

P Silva, A Illanes, L Wilson, R Conejeros - ChemCatChem, 2024 - Wiley Online Library
Multi‐enzyme reaction systems have become an interesting option to avoid transformation
and purification steps in productive reactor‐based systems; when carried out in a single …

[PDF][PDF] Structure of the imine reductase from Ajellomyces dermatitidis in three crystal forms

M Sharma, A Cuetos, A Willliams… - … Section F: Structural …, 2023 - journals.iucr.org
The NADPH-dependent imine reductase from Ajellomyces dermatitidis (AdRedAm)
catalyzes the reductive amination of certain ketones with amine donors supplied in an …