The cerebellum, sensitive periods, and autism

SSH Wang, AD Kloth, A Badura - Neuron, 2014 - cell.com
Cerebellar research has focused principally on adult motor function. However, the
cerebellum also maintains abundant connections with nonmotor brain regions throughout …

Optogenetic tools for subcellular applications in neuroscience

BR Rost, F Schneider-Warme, D Schmitz, P Hegemann - Neuron, 2017 - cell.com
The ability to study cellular physiology using photosensitive, genetically encoded molecules
has profoundly transformed neuroscience. The modern optogenetic toolbox includes …

Thalamic spindles promote memory formation during sleep through triple phase-locking of cortical, thalamic, and hippocampal rhythms

CFV Latchoumane, HVV Ngo, J Born, HS Shin - Neuron, 2017 - cell.com
While the interaction of the cardinal rhythms of non-rapid-eye-movement (NREM) sleep—the
thalamo-cortical spindles, hippocampal ripples, and the cortical slow oscillations—is thought …

Acute brain slice methods for adult and aging animals: application of targeted patch clamp analysis and optogenetics

JT Ting, TL Daigle, Q Chen, G Feng - Patch-clamp methods and protocols, 2014 - Springer
The development of the living acute brain slice preparation for analyzing synaptic function
roughly a half century ago was a pivotal achievement that greatly influenced the landscape …

Precise control of movement kinematics by optogenetic inhibition of Purkinje cell activity

SA Heiney, J Kim, GJ Augustine… - Journal of …, 2014 - Soc Neuroscience
Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with
precision, but a mechanistic explanation of how the activity of these inhibitory neurons …

Polycystic ovary syndrome: understanding the role of the brain

AM Moore, RE Campbell - Frontiers in neuroendocrinology, 2017 - Elsevier
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and the leading cause
of anovulatory infertility. Characterised by hyperandrogenism, menstrual dysfunction and …

Luminopsins integrate opto-and chemogenetics by using physical and biological light sources for opsin activation

K Berglund, K Clissold, HE Li, L Wen… - Proceedings of the …, 2016 - National Acad Sciences
Luminopsins are fusion proteins of luciferase and opsin that allow interrogation of neuronal
circuits at different temporal and spatial resolutions by choosing either extrinsic physical or …

[HTML][HTML] Molecular layer interneurons: key elements of cerebellar network computation and behavior

J Kim, GJ Augustine - Neuroscience, 2021 - Elsevier
Molecular layer interneurons (MLIs) play an important role in cerebellar information
processing by controlling Purkinje cell (PC) activity via inhibitory synaptic transmission. A …

Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression

J Zengel, YX Wang, JW Seo, K Ning, JN Hamilton… - Nature …, 2023 - nature.com
The development of transgenic mouse models that express genes of interest in specific cell
types has transformed our understanding of basic biology and disease. However …

Distinct functional modules for discrete and rhythmic forelimb movements in the mouse motor cortex

R Hira, SI Terada, M Kondo… - Journal of …, 2015 - Soc Neuroscience
Movements of animals are composed of two fundamental dynamics: discrete and rhythmic
movements. Although the movements with distinct dynamics are thought to be differently …