Chromatin accessibility in the Drosophila embryo is determined by transcription factor pioneering and enhancer activation
KJ Brennan, M Weilert, S Krueger, A Pampari, H Liu… - Developmental cell, 2023 - cell.com
Chromatin accessibility is integral to the process by which transcription factors (TFs) read out
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …
Rewiring gene circuitry for plant improvement
AT Borowsky, J Bailey-Serres - Nature Genetics, 2024 - nature.com
Aspirations for high crop growth and yield, nutritional quality and bioproduction of materials
are challenged by climate change and limited adoption of new technologies. Here, we …
are challenged by climate change and limited adoption of new technologies. Here, we …
[HTML][HTML] Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types
The human genome contains millions of candidate cis-regulatory elements (CREs) with cell-
type-specific activities that shape both health and myriad disease states. However, we lack a …
type-specific activities that shape both health and myriad disease states. However, we lack a …
Massively parallel characterization of regulatory elements in the developing human cortex
Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and diseases. Using massively parallel reporter assays in primary human cells …
development and diseases. Using massively parallel reporter assays in primary human cells …
Emerging insights into enhancer biology and function
M Arnold, KR Stengel - Transcription, 2023 - Taylor & Francis
Cell type-specific gene expression is coordinated by DNA-encoded enhancers and the
transcription factors (TFs) that bind to them in a sequence-specific manner. As such, these …
transcription factors (TFs) that bind to them in a sequence-specific manner. As such, these …
Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection
Memory B cells (MBCs) are key providers of long-lived immunity against infectious disease,
yet in chronic viral infection, they do not produce effective protection. How chronic viral …
yet in chronic viral infection, they do not produce effective protection. How chronic viral …
[HTML][HTML] Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex
Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and disease. Using massively parallel reporter assays in primary human cells …
development and disease. Using massively parallel reporter assays in primary human cells …
EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release
K Mukherjee, JJ Bieker - Cell reports, 2022 - cell.com
EKLF/Klf1 is a zinc-finger transcription activator essential for erythroid lineage commitment
and terminal differentiation. Using ChIP-seq, we investigate EKLF DNA binding and …
and terminal differentiation. Using ChIP-seq, we investigate EKLF DNA binding and …
Physical interaction between MSL2 and CLAMP assures direct cooperativity and prevents competition at composite binding sites
N Eggers, F Gkountromichos, S Krause… - Nucleic Acids …, 2023 - academic.oup.com
MSL2, the DNA-binding subunit of the Drosophila dosage compensation complex,
cooperates with the ubiquitous protein CLAMP to bind MSL recognition elements (MREs) on …
cooperates with the ubiquitous protein CLAMP to bind MSL recognition elements (MREs) on …
Chromatin accessibility is a two-tier process regulated by transcription factor pioneering and enhancer activation
KJ Brennan, M Weilert, S Krueger, A Pampari, HY Liu… - bioRxiv, 2022 - biorxiv.org
Chromatin accessibility is integral to the process by which transcription factors (TFs) read out
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …