This review is intended to provide a broad outline of the biological and molecular functions
of MYC as well as of the larger protein network within which MYC operates. We present a …

Abstract MYC proteins (c-MYC, MYCN, and MYCL) regulate processes involved in many if
not all aspects of cell fate. Therefore, it is not surprising that the MYC genes are deregulated …

The nuclease hypersensitivity element III1 upstream of the P1 promoter of c-MYC controls 85–
90% of the transcriptional activation of this gene. We have demonstrated that the purine-rich …

Murine ES cells can be maintained as a pluripotent, self-renewing population by LIF/STAT3-
dependent signaling. The downstream effectors of this pathway have not been previously …

Hematopoiesis is a process capable of generating millions of cells every second, as
distributed in many cell types. The process is regulated by a number of transcription factors …

The epidermis contains two types of proliferative keratinocyte: stem cells, with unlimited self-
renewal capacity, and transit amplifying cells, those daughters of stem cells that are destined …

ABSTRACT A major dilemma facing the Myc researcher is understanding how c‐Myc
regulation of gene transcription translates into the proliferative and oncogenic activities …

The last few years have brought about many changes in the field of marine and freshwater
toxins, with advances in analytical technology and the realization that these toxins are a …

Coordination of cellular processes through the establishment of tissue-specific gene
expression programs is essential for lineage maturation. The basic helix-loop-helix …

The nuclease hypersensitivity element III1 (NHE III1) in the c-MYC promoter controls up to
80–90% of the transcriptional activity of this gene. We have demonstrated that the guanine …