Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

Developing, regenerating, and repairing a lung all require interstitial resident fibroblasts
(iReFs) to direct the behavior of the epithelial stem cell niche. During lung development …

Rationale: Conventional 3-dimensional (3D) printing techniques cannot produce structures
of the size at which individual cells interact. Objective: Here, we used multiphoton-excited …

Cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs) offer
tremendous potential when used to engineer human tissues for drug screening and disease …

During embryonic morphogenesis, the heart undergoes a complex series of cellular
phenotypic maturations (eg, transition of myocytes from proliferative to quiescent or …

End‐stage organ failure is a devastating problem with limited therapeutic options. The
definitive treatment is orthotropic transplantation, however, there exists a severe shortage of …

Solid organ fabrication is an ultimate goal of Regenerative Medicine. Since the introduction
of Tissue Engineering in 1993, functional biomaterials, stem cells, tunable …

Rationale: After birth, cycling mammalian CMs (cardiomyocytes) progressively lose the
ability to undergo cytokinesis and hence they become binucleated, which leads to cell cycle …

Current strategies for engineering cardiovascular cells and tissues have yielded a variety of
sophisticated tools for studying disease mechanisms, for development of drug therapies …

A main challenge in cardiac tissue engineering is the limited data on microenvironmental
cues that sustain survival, proliferation and functional proficiency of cardiac cells. The aim of …