A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

J Peng, M Fan, C An, F Ni, W Huang… - Basic & clinical …, 2022 - Wiley Online Library
Cannabidiol (CBD) is an abundant non‐psychoactive phytocannabinoid in cannabis
extracts which has high affinity on a series of receptors, including Type 1 cannabinoid …

[HTML][HTML] Pharmacotherapy of anxiety disorders: current and emerging treatment options

A Garakani, JW Murrough, RC Freire, RP Thom… - Frontiers in …, 2020 - frontiersin.org
Anxiety disorders are the most prevalent psychiatric disorders and a leading cause of
disability. While there continues to be expansive research in posttraumatic stress disorder …

Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis

N Black, E Stockings, G Campbell, LT Tran… - The Lancet …, 2019 - thelancet.com
Background Medicinal cannabinoids, including medicinal cannabis and pharmaceutical
cannabinoids and their synthetic derivatives, such as tetrahydrocannabinol (THC) and …

Cannabidiol: pharmacology and therapeutic targets

SC Britch, S Babalonis, SL Walsh - Psychopharmacology, 2021 - Springer
Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-
treat a myriad of conditions and for their unsubstantiated health benefits. The scientific …

[HTML][HTML] A systematic review on the pharmacokinetics of cannabidiol in humans

SA Millar, NL Stone, AS Yates… - Frontiers in …, 2018 - frontiersin.org
Background: Cannabidiol is being pursued as a therapeutic treatment for multiple
conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but …

Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems

J Moltke, C Hindocha - Journal of cannabis research, 2021 - Springer
Background Public and medical interest in cannabidiol (CBD) has been rising, and CBD is
now available from various sources. Research into the effects of low-dose CBD on outcomes …

Cannabidiol (CBD) as an adjunctive therapy in schizophrenia: a multicenter randomized controlled trial

P McGuire, P Robson, WJ Cubala… - American Journal of …, 2018 - Am Psychiatric Assoc
Objective: Research in both animals and humans indicates that cannabidiol (CBD) has
antipsychotic properties. The authors assessed the safety and effectiveness of CBD in …

Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders

MS García-Gutiérrez, F Navarrete, A Gasparyan… - Biomolecules, 2020 - mdpi.com
The potential therapeutic use of some Cannabis sativa plant compounds has been attracting
great interest, especially for managing neuropsychiatric disorders due to the relative lack of …

Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

D De Gregorio, RJ McLaughlin, L Posa… - Pain, 2019 - journals.lww.com
Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …

Cannabidiol: State of the art and new challenges for therapeutic applications

S Pisanti, AM Malfitano, E Ciaglia, A Lamberti… - Pharmacology & …, 2017 - Elsevier
Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9-THC and cannabidiol (CBD) are the …