Phages differ substantially in the bacterial hosts that they infect. Their host range is
determined by the specific structures that they use to target bacterial cells. Tailed phages …

Purpose Widespread antibiotic-resistant bacteria are threatening the arsenal of existing
antibiotics. Not only are antibiotics less likely to be effective today, but their extensive use …

Bacteria that cause life-threatening infections in humans are becoming increasingly difficult
to treat. In some instances, this is due to intrinsic and acquired antibiotic resistance …

Antibiotic use not only underpins modern medicine, but has brought huge changes to the
world, especially in expectations of survival of children into adulthood. The theme of World …

Summary In 1979, Richard Law introduced the conceptual idea of the 'Darwinian Demon':
an organism that simultaneously maximizes all fitness traits [1]. Such an organism would …

With the increasing global threat of antibiotic resistance, there is an urgent need to develop
new effective therapies to tackle antibiotic-resistant bacterial infections. Bacteriophage …

Complex interactions between bacteriophages and their bacterial hosts play significant roles
in shaping the structure of environmental microbial communities, not only by genetic …

Bacteriophages have long been recognized for their potential as biotherapeutic agents. The
recent approval for the use of phages of Listeria monocytogenes for food safety purposes …

Background Bacteriophages specific for Yersinia pestis are routinely used for plague
diagnostics and could be an alternative to antibiotics in case of drug-resistant plague. A …

The phage life cycle is a multi-stage process initiated by the recognition and attachment of
the virus to its bacterial host. This adsorption step depends on the specific interaction …