Circadian clocks and metabolism

B Marcheva, KM Ramsey, CB Peek, A Affinati, E Maury… - Circadian clocks, 2013 - Springer
Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and
metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals …

Circadian dysfunction in disease

DA Bechtold, JE Gibbs, ASI Loudon - Trends in pharmacological sciences, 2010 - cell.com
The classic view of circadian timing in mammals emphasizes a light-responsive 'master
clock'within the hypothalamus which imparts temporal information to the organism. Recent …

Clock genes and clock-controlled genes in the regulation of metabolic rhythms

G Mazzoccoli, V Pazienza… - Chronobiology …, 2012 - Taylor & Francis
Daily rotation of the Earth on its axis and yearly revolution around the Sun impose to living
organisms adaptation to nyctohemeral and seasonal periodicity. Terrestrial life forms have …

Circadian clocks and breast cancer

V Blakeman, JL Williams, QJ Meng, CH Streuli - Breast Cancer Research, 2016 - Springer
Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in
almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic …

Peripheral circadian oscillators in mammals

SA Brown, A Azzi - Circadian clocks, 2013 - Springer
Although circadian rhythms in mammalian physiology and behavior are dependent upon a
biological clock in the suprachiasmatic nuclei (SCN) of the hypothalamus, the molecular …

Circadian rhythms and cancer

S Gery, HP Koeffler - Cell cycle, 2010 - Taylor & Francis
The circadian clock is an endogenous time keeping system shared by most organisms. In
mammals, a master pacemaker in the hypothalamus orchestrates temporal alignment of …

Synthetic progestins medroxyprogesterone acetate and dydrogesterone and their binary mixtures adversely affect reproduction and lead to histological and …

Y Zhao, S Castiglioni, K Fent - Environmental science & …, 2015 - ACS Publications
Medroxyprogesterone acetate (MPA) and dydrogesterone (DDG) are synthetic progestins
widely used in human and veterinary medicine. Although aquatic organisms are exposed to …

Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells

C De Mei, L Ercolani, C Parodi, M Veronesi… - Oncogene, 2015 - nature.com
Abstract REV-ERBα and REV-ERBβ nuclear receptors regulate several physiological
processes, including circadian rhythm and metabolism. A previous study reported the REV …

Nutrient sensing and the circadian clock

CB Peek, KM Ramsey, B Marcheva, J Bass - Trends in Endocrinology & …, 2012 - cell.com
The circadian system synchronizes behavioral and physiologic processes with daily
changes in the external light–dark cycle, optimizing energetic cycles with the rising and …

Circadian rhythms: from basic mechanisms to the intensive care unit

MC Chan, PM Spieth, K Quinn, M Parotto… - Critical care …, 2012 - journals.lww.com
Objective: Circadian rhythms are intrinsic timekeeping mechanisms that allow for adaptation
to cyclic environmental changes. Increasing evidence suggests that circadian rhythms may …