Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …

Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic
function of brown adipose tissue (BAT) and contributes to the maintenance of body …

Diabetes and its chronic complications still represent a great clinical problem, despite
improvements made in the diagnosis and treatment of the disease. People with diabetes …

Brown and beige adipocytes arise from distinct developmental origins. Brown adipose tissue
(BAT) develops embryonically from precursors that also give to skeletal muscle. Beige fat …

Energy balance—that is, the relationship between energy intake and energy expenditure—
is regulated by a complex interplay of hormones, brain circuits and peripheral tissues. Leptin …

Running wheels are commonly employed to measure rodent physical activity in a variety of
contexts, including studies of energy balance and obesity. There is no consensus on the …

Brain-derived neurotrophic factor (BDNF) mediates energy metabolism and feeding
behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival during early …

A changing environment and lifestyle on the background of evolutionary engraved and
perinatally imprinted physiological response patterns is the foremost explanation for the …

Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are expressed in several
hypothalamic and hindbrain nuclei involved in regulating energy homeostasis …

Obesity represents a major risk factor for the development of several of our most common
medical conditions, including Type 2 diabetes, dyslipidaemia, non-alcoholic fatty liver …