Cell growth (an increase in cell mass and size through macromolecular biosynthesis) and
cell cycle progression are generally tightly coupled, allowing cells to proliferate continuously …

Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among
phospholipids in that its head group can be phosphorylated at multiple free hydroxyls …

The complex of rapamycin with its intracellular receptor, FKBP12, interacts with
RAFT1/FRAP/mTOR, the in vivo rapamycin-sensitive target and a member of the ataxia …

Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in
a multitude of cellular processes, ranging from control of fundamental cell autonomous …

Objective: Rapamune is a novel immunosuppressive agent in Phase III clinical trial in renal
transplantation. Its unique mechanism of action has created great interest in its use as a …

The proteins eIF-4E BP1 and p70 S6 kinase each undergo an insulin/mitogen-stimulated
phosphorylation in situ that is partially inhibited by rapamycin. Previous work has …

The immunosuppressant, rapamycin, inhibits cell growth by interfering with the function of a
novel kinase, termed mammalian target of rapamycin (mTOR). The putative catalytic domain …

Rapamycin in transplantation: A review of the evidence. The calcineurin inhibitors have
been the mainstays of immunosuppression for solid organ transplantation over the last two …

Rapamycin has potent immunosuppressive properties reflecting its ability to disrupt cytokine
signaling that promotes lymphocyte growth and differentiation. In IL-2-stimulated T cells …

Recently, a number of cDNA clones with homology to the catalytic subunit of
phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone …