Secondary somatic mutations in G-protein-related pathways and mutation signatures in uveal melanoma
Background: Uveal melanoma (UM), a rare cancer of the eye, is characterized by initiating
mutations in the genes G-protein subunit alpha Q (GNAQ), G-protein subunit alpha 11 …
mutations in the genes G-protein subunit alpha Q (GNAQ), G-protein subunit alpha 11 …
Comparative study on driver mutations in primary and metastatic melanomas at a single Japanese institute: A clue for intra-and inter-tumor heterogeneity
T Kaji, O Yamasaki, M Takata, M Otsuka… - Journal of …, 2017 - Elsevier
Background Searching for driver mutations in melanoma is critical to understanding
melanoma genesis, progression and response to therapy. Objectives We aimed to …
melanoma genesis, progression and response to therapy. Objectives We aimed to …
Reduced EphB6 protein in gastric carcinoma and associated lymph nodes suggests EphB6 as a gastric tumor and metastasis inhibitor
J Liu, B Xu, G Xu, X Zhang, X Yang… - Cancer Biomarkers, 2017 - content.iospress.com
BACKGROUND: Eph receptors comprise the largest group of the receptor tyrosine kinase
(RTK) family, and Eph receptors interacting with their ligand ephrins play an important role in …
(RTK) family, and Eph receptors interacting with their ligand ephrins play an important role in …
[HTML][HTML] Treatment of primary and metastatic multifocal mucosal melanoma of the oral cavity with imatinib
T Deinlein, IH Wolf, B Rainer, R Kupsa… - Case reports in …, 2017 - karger.com
Background: Mucosal melanoma of the oral cavity is a rare entity and accounts for less than
1–3% of all melanomas. Contrary to cutaneous melanoma, primary oral melanoma more …
1–3% of all melanomas. Contrary to cutaneous melanoma, primary oral melanoma more …
Impact of genomics on the surgical management of melanoma
Background Although surgery for early-stage melanoma offers the best chance of cure,
recent advances in molecular medicine have revolutionized the management of late-stage …
recent advances in molecular medicine have revolutionized the management of late-stage …
The frequency and clinicopathological significance of NRAS mutations in primary cutaneous nodular melanoma in Indonesia
HT Rinonce, DJ Sastri, F Trisnawati… - Cancer …, 2022 - Wiley Online Library
Background Melanoma is a lethal skin malignancy with a high risk of metastasis, which
prompts a need for research on treatment targets and prognostic factors. Recent studies …
prompts a need for research on treatment targets and prognostic factors. Recent studies …
[PDF][PDF] Prevalence of BRAF V600E and NRAS (G12V, G13V) mutations in Iranian patients with melanoma and their association with tumor-related factors
A Ghanadan, R Shirkoohi, R Shahsiah… - Iranian Journal of …, 2024 - iranjd.ir
Background: NRAS and BRAF mutations are commonly reported in melanoma with various
frequencies in different countries. However, their correlation with the development of …
frequencies in different countries. However, their correlation with the development of …
From genetic data and structures to drug development: New approaches to target Eph receptors
DB Nikolov, JP Himanen - … Mechanisms and the Advancing Approaches to …, 2021 - Elsevier
The Eph receptors are the largest receptor tyrosine kinase (RTK) group. The Ephs and their
ephrin ligands are expressed in many tissues during development and in the adult organism …
ephrin ligands are expressed in many tissues during development and in the adult organism …
[PDF][PDF] Comparative study on driver mutations in primary and metastatic melanomas at a single Japanese institute: A clue for intraand inter-tumor heterogeneity
T Kaji - 2017 - ousar.lib.okayama-u.ac.jp
Background: Searching for driver mutations in melanoma is critical to understanding
melanoma genesis, progression and response to therapy. Objectives: We aimed to …
melanoma genesis, progression and response to therapy. Objectives: We aimed to …