In the past decade, interest in pyrazole chemistry has significatively increased mainly due to
the discovery of the interesting properties exhibited by a great number of pyrazole …

Pyrazoles are of considerable interest due to the broad variety of their biological activities.
This overview summarizes structures of pharmacologically interesting pyrazoles, natural …

Fluorine, the most electronegative element plays nowadays a key role in pharmaceutical,
agrochemical and material sciences. It has been estimated that the number of fluorinated …

Pyrazole (Figure 1), a five-membered, two-nitrogen-containing heterocycle ring, is widely
found as the core structure in a large variety of compounds that possess important …

We report the discovery and medicinal chemistry optimization of a novel series of pyrazole-
based inhibitors of human lactate dehydrogenase (LDH). Utilization of a quantitative high …

The preparation of N-methylpyrazoles is usually accomplished through reaction of a suitable
1, 3-diketone with methylhydrazine in ethanol as the solvent. This strategy, however, leads …

Selected 1, 3-diketones having a trifluoromethyl group and/or a fluorine in the 2-position
were condensed with aromatic hydrazines, hydroxylamine, urea, thiourea, guanidine, and …

An efficient [3+ 2] cycloaddition reaction between in situ generated nitrile imines from
hydrazonoyl halides and vinylsulfonium salts is developed. The nitrile imines are …

A detailed study of the reaction of trifluoroacetylated acetylenes and aryl (alkyl) hydrazines
was performed, aimed to the regioselective synthesis of 3-or 5-trifluoromethylated pyrazoles …

Kinetic data for reactions between phenyl hydrazine and 1, 3-diketones (Knorr pyrazole
synthesis) were acquired by using transient flow methods. Supported by further …