A review of 25 years of the social interaction test
SE File, P Seth - European journal of pharmacology, 2003 - Elsevier
The social interaction test of anxiety was developed 25 years ago to provide an ethologically
based test that was sensitive to both anxiolytic and anxiogenic effects. It is sensitive to a …
based test that was sensitive to both anxiolytic and anxiogenic effects. It is sensitive to a …
Stress-induced prefrontal reorganization and executive dysfunction in rodents
A Holmes, CL Wellman - Neuroscience & Biobehavioral Reviews, 2009 - Elsevier
The prefrontal cortex (PFC) mediates a range of higher order 'executive functions' that
subserve the selection and processing of information in such a way that behavior can be …
subserve the selection and processing of information in such a way that behavior can be …
Chronic restraint stress causes anxiety-and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced …
S Chiba, T Numakawa, M Ninomiya… - Progress in Neuro …, 2012 - Elsevier
Stress and the resulting increase in glucocorticoid levels have been implicated in the
pathophysiology of depressive disorders. We investigated the effects of chronic restraint …
pathophysiology of depressive disorders. We investigated the effects of chronic restraint …
[HTML][HTML] Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety
A Adhikari, MA Topiwala, JA Gordon - Neuron, 2010 - cell.com
The ventral hippocampus, unlike its dorsal counterpart, is required for anxiety-like behavior.
The means by which it acts are unknown. We hypothesized that the hippocampus …
The means by which it acts are unknown. We hypothesized that the hippocampus …
Single units in the medial prefrontal cortex with anxiety-related firing patterns are preferentially influenced by ventral hippocampal activity
A Adhikari, MA Topiwala, JA Gordon - Neuron, 2011 - cell.com
The medial prefrontal cortex (mPFC) and ventral hippocampus (vHPC) functionally interact
during innate anxiety tasks. To explore the consequences of this interaction, we examined …
during innate anxiety tasks. To explore the consequences of this interaction, we examined …
The periaqueductal gray and primal emotional processing critical to influence complex defensive responses, fear learning and reward seeking
The periaqueductal gray (PAG) has been commonly recognized as a downstream site in
neural networks for the expression of a variety of behaviors and is thought to provide …
neural networks for the expression of a variety of behaviors and is thought to provide …
Long-range neural synchrony in behavior
Long-range synchrony between distant brain regions accompanies multiple forms of
behavior. This review compares and contrasts the methods by which long-range synchrony …
behavior. This review compares and contrasts the methods by which long-range synchrony …
Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia
CA Wilson, JI Koenig - European Neuropsychopharmacology, 2014 - Elsevier
Negative symptoms (eg, asociality and anhedonia) are a distinct symptomatic domain that
has been found to significantly affect the quality of life in patients diagnosed with …
has been found to significantly affect the quality of life in patients diagnosed with …
Animal to human translational paradigms relevant for approach avoidance conflict decision making
Avoidance behavior in clinical anxiety disorders is often a decision made in response to
approach-avoidance conflict, resulting in a sacrifice of potential rewards to avoid potential …
approach-avoidance conflict, resulting in a sacrifice of potential rewards to avoid potential …
Excitotoxic lesions of the medial prefrontal cortex attenuate fear responses in the elevated-plus maze, social interaction and shock probe burying tests
AA Shah, D Treit - Brain research, 2003 - Elsevier
Previous research investigating the effects of medial prefrontal cortex (MPFC) lesions on
fear-and anxiety-related behavior has yielded an inconsistent body of findings. Behavioral …
fear-and anxiety-related behavior has yielded an inconsistent body of findings. Behavioral …