Patterns are ubiquitous in living systems and underlie the dynamic organization of cells,
tissues, and embryos. Mathematical frameworks have been devised to account for the self …

BACKGROUND Pluripotent cells are generated by embryonic divisions that occur shortly
after fertilization. These cells are transformed into the recognizable outline of an organism …

Cell apical constriction driven by actomyosin contraction forces is a conserved mechanism
during tissue folding in embryo development. While much is now understood of the …

Cytoplasmic flows are widely emerging as key functional players in development. In early
Drosophila embryos, flows drive the spreading of nuclei across the embryo. Here, we …

Convergent extension of epithelial tissue is a key motif of animal morphogenesis. On a
coarse scale, cell motion resembles laminar fluid flow; yet in contrast to a fluid, epithelial …

During early development of multi-cellular animals, cells self-organize to set up the body
axes, such as the primary head-to-tail axis, based on which the later body plan is defined …

Cell fate decisions emerge as a consequence of a complex set of gene regulatory networks.
Models of these networks are known to have more parameters than data can determine …

The actomyosin cytoskeleton is a crucial driver of morphogenesis. Yet how the behavior of
large-scale cytoskeletal patterns in deforming tissues emerges from the interplay of …

The importance of physical forces in the morphogenesis, homeostatic function, and
pathological dysfunction of multicellular tissues is being increasingly characterized, both …

Abstract Development and disease are regulated by the interplay between genetics and the
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …