The impact of maternal high-fat diet on offspring neurodevelopment

G Urbonaite, A Knyzeliene, FS Bunn… - Frontiers in …, 2022 - frontiersin.org
A maternal high-fat diet affects offspring neurodevelopment with long-term consequences on
their brain health and behavior. During the past three decades, obesity has rapidly …

LPS versus Poly I: C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring

M Bao, N Hofsink, T Plösch - American Journal of …, 2022 - journals.physiology.org
A prominent health issue nowadays is the COVID-19 pandemic, which poses acute risks to
human health. However, the long-term health consequences are largely unknown and …

[HTML][HTML] Maternal immune activation in rodent models: A systematic review of neurodevelopmental changes in gene expression and epigenetic modulation in the …

RM Woods, JM Lorusso, HG Potter, JC Neill… - Neuroscience & …, 2021 - Elsevier
Maternal immune activation (mIA) during pregnancy is hypothesised to disrupt offspring
neurodevelopment and predispose offspring to neurodevelopmental disorders such as …

Could psychedelic drugs have a role in the treatment of schizophrenia? Rationale and strategy for safe implementation

G Wolf, S Singh, K Blakolmer, L Lerer, T Lifschytz… - Molecular …, 2023 - nature.com
Schizophrenia is a widespread psychiatric disorder that affects 0.5–1.0% of the world's
population and induces significant, long-term disability that exacts high personal and …

[HTML][HTML] Microglia and BDNF at the crossroads of stressor related disorders: Towards a unique trophic phenotype

N Prowse, S Hayley - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Stressors ranging from psychogenic/social to neurogenic/injury to systemic/microbial can
impact microglial inflammatory processes, but less is known regarding their effects on …

First episode psychosis and schizophrenia are systemic neuro-immune disorders triggered by a biotic stimulus in individuals with reduced immune regulation and …

M Maes, K Plaimas, A Suratanee, C Noto… - Cells, 2021 - mdpi.com
There is evidence that schizophrenia is characterized by activation of the immune-
inflammatory response (IRS) and compensatory immune-regulatory systems (CIRS) and …

[HTML][HTML] Transgenerational epigenetic impacts of parental infection on offspring health and disease susceptibility

EA Kleeman, C Gubert, AJ Hannan - Trends in Genetics, 2022 - cell.com
Maternal immune activation (MIA) and infection during pregnancy are known to
reprogramme offspring phenotypes. However, the epigenetic effects of preconceptual …

Schizophrenia synaptic pathology and antipsychotic treatment in the framework of oxidative and mitochondrial dysfunction: translational highlights for the clinics and …

G De Simone, B Mazza, L Vellucci, A Barone… - Antioxidants, 2023 - mdpi.com
Schizophrenia is a worldwide mental illness characterized by alterations at dopaminergic
and glutamatergic synapses resulting in global dysconnectivity within and between brain …

Effects of a six-month yoga intervention on the immune-inflammatory pathway in antipsychotic-stabilized schizophrenia patients: A randomized controlled trial

T Mullapudi, M Debnath, R Govindaraj, P Raj… - Asian Journal of …, 2023 - Elsevier
Background Schizophrenia is a complex neuropsychiatric disorder for which several
etiopathological theories have been proposed, one of the prominent ones being immune …

Maternal immune activation induces autism-like behavior and reduces brain-derived neurotrophic factor levels in the hippocampus and offspring cortex of C57BL/6 …

ML Dutra, P Dias, V Freiberger, L Ventura… - Neuroscience …, 2023 - Elsevier
Prenatal factors such as viral or bacterial infections occurring mainly during the first
trimesters of pregnancy can increase the incidence of autism spectrum disorder (ASD) in …