Protein phosphorylation: a major switch mechanism for metabolic regulation
Metabolism research is undergoing a renaissance because many diseases are increasingly
recognized as being characterized by perturbations in intracellular metabolic regulation …
recognized as being characterized by perturbations in intracellular metabolic regulation …
What is the total number of protein molecules per cell volume? A call to rethink some published values
R Milo - Bioessays, 2013 - Wiley Online Library
Novel methods such as mass‐spectrometry enable a view of the proteomes of cells in
unprecedented detail. Recently, these efforts have culminated in quantitative measurements …
unprecedented detail. Recently, these efforts have culminated in quantitative measurements …
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues
Abstract Genome‐, transcriptome‐and proteome‐wide measurements provide insights into
how biological systems are regulated. However, fundamental aspects relating to which …
how biological systems are regulated. However, fundamental aspects relating to which …
[HTML][HTML] A quantitative proteome map of the human body
Determining protein levels in each tissue and how they compare with RNA levels is
important for understanding human biology and disease as well as regulatory processes …
important for understanding human biology and disease as well as regulatory processes …
The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
MaxQuant is one of the most frequently used platforms for mass-spectrometry (MS)-based
proteomics data analysis. Since its first release in 2008, it has grown substantially in …
proteomics data analysis. Since its first release in 2008, it has grown substantially in …
[HTML][HTML] Global phosphoproteomic analysis of human skeletal muscle reveals a network of exercise-regulated kinases and AMPK substrates
NJ Hoffman, BL Parker, R Chaudhuri… - Cell metabolism, 2015 - cell.com
Exercise is essential in regulating energy metabolism and whole-body insulin sensitivity. To
explore the exercise signaling network, we undertook a global analysis of protein …
explore the exercise signaling network, we undertook a global analysis of protein …
Mass-spectrometry-based draft of the human proteome
Proteomes are characterized by large protein-abundance differences, cell-type-and time-
dependent expression patterns and post-translational modifications, all of which carry …
dependent expression patterns and post-translational modifications, all of which carry …
Multidimensional proteomics for cell biology
The proteome is a dynamic system in which each protein has interconnected properties—
dimensions—that together contribute to the phenotype of a cell. Measuring these properties …
dimensions—that together contribute to the phenotype of a cell. Measuring these properties …
The gut microbiota modulates host amino acid and glutathione metabolism in mice
A Mardinoglu, S Shoaie, M Bergentall… - Molecular systems …, 2015 - embopress.org
The gut microbiota has been proposed as an environmental factor that promotes the
progression of metabolic diseases. Here, we investigated how the gut microbiota modulates …
progression of metabolic diseases. Here, we investigated how the gut microbiota modulates …
Serine catabolism feeds NADH when respiration is impaired
NADH provides electrons for aerobic ATP production. In cells deprived of oxygen or with
impaired electron transport chain activity, NADH accumulation can be toxic. To minimize …
impaired electron transport chain activity, NADH accumulation can be toxic. To minimize …