Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy
JA Spudich, N Nandwani, J Robert-Paganin… - The EMBO …, 2024 - embopress.org
Human β-cardiac myosin exists in an ON-state where both myosin heads are accessible for
interaction with actin, and an OFF-state where the heads are folded back onto their own …
interaction with actin, and an OFF-state where the heads are folded back onto their own …
[HTML][HTML] Calcium has a direct effect on thick filament activation in porcine myocardium
Sarcomere activation in striated muscle requires both thin filament–based and thick filament–
based activation mechanisms. Recent studies have shown that myosin heads on the thick …
based activation mechanisms. Recent studies have shown that myosin heads on the thick …
[HTML][HTML] Harnessing molecular mechanism for precision medicine in dilated cardiomyopathy caused by a mutation in troponin T
L Greenberg, WT Stump, Z Lin, AL Bredemeyer… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Familial dilated cardiomyopathy (DCM) is frequently caused by autosomal dominant point
mutations in genes involved in diverse cellular processes, including sarcomeric contraction …
mutations in genes involved in diverse cellular processes, including sarcomeric contraction …
[HTML][HTML] Dual effect of N-terminal deletion of cardiac myosin essential light chain in mitigating cardiomyopathy
YH Sitbon, K Kazmierczak, J Liang, AJ Kloehn, J Vinod… - Iscience, 2024 - cell.com
We investigated the role of the N-terminus (residues 1–43) of the myosin essential light
chain (N-ELC) in regulating cardiac function in hypertrophic (HCM-A57G) and restrictive …
chain (N-ELC) in regulating cardiac function in hypertrophic (HCM-A57G) and restrictive …
Cardiac length-dependent activation driven by force-dependent thick-filament dynamics
The length-dependent activation (LDA) of maximum force and calcium sensitivity are
established features of cardiac muscle contraction but the dominant underlying mechanisms …
established features of cardiac muscle contraction but the dominant underlying mechanisms …
Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically
At the molecular level, clinical hypercontractility associated with many hypertrophic
cardiomyopathy (HCM)-causing mutations in beta-cardiac myosin appears to be driven by …
cardiomyopathy (HCM)-causing mutations in beta-cardiac myosin appears to be driven by …