Host defense mechanisms against Mycobacterium tuberculosis

Q Chai, Z Lu, CH Liu - Cellular and Molecular Life Sciences, 2020 - Springer
Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains the
leading cause of death worldwide from a single infectious pathogen. Mtb is a paradigmatic …

Can we predict tuberculosis cure? What tools are available?

D Goletti, CSL Arlehamn, TJ Scriba… - European …, 2018 - Eur Respiratory Soc
Antibiotic treatment of tuberculosis takes≥ 6 months, putting a major burden on patients and
health systems in large parts of the world. Treatment beyond 2 months is needed to prevent …

Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis: a cross-sectional study

X Liu, X Bai, R Ren, L Tan, Y Zhang, H Lan… - Frontiers in …, 2022 - frontiersin.org
Background Depression and anxiety are major psychological issues among patients with
tuberculosis (TB) owing to chronic and complex treatments, have been reported to be …

Advancing personalized medicine for tuberculosis through the application of immune profiling

VTA Thu, LD Dat, RP Jayanti, HKT Trinh… - Frontiers in Cellular …, 2023 - frontiersin.org
While early and precise diagnosis is the key to eliminating tuberculosis (TB), conventional
methods using culture conversion or sputum smear microscopy have failed to meet demand …

Immune disturbances in female genital tuberculosis and latent genital tuberculosis

JB Sharma, S Sharma, E Sharma… - American Journal of …, 2023 - Wiley Online Library
Background Female genital tuberculosis (FGTB), an important clinical sub‐type of extra‐
pulmonary tuberculosis (EPTB) is responsible for about 10% cases of infertility in India. Both …

Tuberculosis, the disrupted immune-endocrine response and the potential thymic repercussion as a contributing factor to disease physiopathology

L D'Attilio, N Santucci, B Bongiovanni… - Frontiers in …, 2018 - frontiersin.org
Upon the pathogen encounter, the host seeks to ensure an adequate inflammatory reaction
to combat infection but at the same time tries to prevent collateral damage, through several …

Steroid hormone modulates the production of cathelicidin and human β-defensins in lung epithelial cells and macrophages promoting Mycobacterium tuberculosis …

SP Marin-Luevano, A Rodriguez-Carlos… - Tuberculosis, 2021 - Elsevier
Several studies have documented the interaction between the immune and endocrine
systems as an effective defense strategy against tuberculosis, involving the production of …

Enhanced Anti-Mycobacterium tuberculosis Immunity over Time with Combined Drug and Immunotherapy Treatment

SE Larsen, SL Baldwin, MT Orr, VA Reese, T Pecor… - Vaccines, 2018 - mdpi.com
It is estimated that one third of the world's population is infected with Mycobacterium
tuberculosis (Mtb). This astounding statistic, in combination with costly and lengthy treatment …

Past and present approaches to diagnosis of active pulmonary tuberculosis

AR Namuganga, NN Chegou… - Frontiers in Medicine, 2021 - frontiersin.org
Tuberculosis disease continues to contribute to the mortality burden globally. Due to the
several shortcomings of the available diagnostic methods, tuberculosis disease continues to …

The Immunoregulatory Actions of DHEA in Tuberculosis, A Tool for Therapeutic Intervention?

B Bongiovanni, A Díaz, N Santucci… - Frontiers in …, 2022 - frontiersin.org
Dehydroepiandrosterone (DHEA) is an androgen synthesized by the adrenal cortex, which
is an intermediary in the biosynthesis of sex hormones, such as testosterone and estradiol …